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http://hdl.handle.net/2445/181477
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DC Field | Value | Language |
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dc.contributor.author | Juszczyk, Ewelina | - |
dc.contributor.author | Kulinowski, Piotr | - |
dc.contributor.author | Baran, Ewelina | - |
dc.contributor.author | Birczynski, Artur | - |
dc.contributor.author | Klaja, Jolanta | - |
dc.contributor.author | Majda, Dorota | - |
dc.contributor.author | García Montoya, Encarna | - |
dc.contributor.author | Weglarz, Wladyslaw P. | - |
dc.contributor.author | Dorozynski, Przemyslaw | - |
dc.date.accessioned | 2021-11-25T10:57:05Z | - |
dc.date.available | 2021-11-25T10:57:05Z | - |
dc.date.issued | 2021-10-30 | - |
dc.identifier.issn | 1996-1944 | - |
dc.identifier.uri | http://hdl.handle.net/2445/181477 | - |
dc.description.abstract | The purpose was to show, using destructive/nondestructive methods, that the interplay between water, tablet structure, and composition determine the unique spatiotemporal hydration pattern of polymer-based matrices. The tablets containing a 1:1 w/w mixture of sodium alginate with salicylic acid (ALG/SA) or sodium salicylate (ALG/SNA) were studied using Karl Fischer titration, differential scanning calorimetry, x-ray microtomography, and magnetic resonance imaging. As the principal results, matrix specific features were detected, e.g., 'locking' of the internal part of the matrix (ALG/SA); existence of lamellar region associated with detection of free/freezing water (ALG/SA); existence of water penetrating the matrix forming specific region preceding infiltration layer (ALG/SNA); switch in the onset temperature of endothermic water peak associated with an increase in the fraction of non-freezing water weight per dry matrix weight in the infiltration layer (ALG/SNA). The existence of complicated spatiotemporal hydration patterns influenced by matrix composition and molecular properties of constituents has been demonstrated. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/ma14216531 | - |
dc.relation.ispartof | Materials, 2021, vol. 14, p. 6531 | - |
dc.rights | cc-by (c) Juszczyk, Ewelina et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) | - |
dc.subject.classification | Polímers | - |
dc.subject.classification | Sistemes d'alliberament de medicaments | - |
dc.subject.classification | Síntesi de fàrmacs | - |
dc.subject.classification | Nanopartícules | - |
dc.subject.other | Polymers | - |
dc.subject.other | Drug delivery systems | - |
dc.subject.other | Drug synthesis | - |
dc.subject.other | Nanoparticles | - |
dc.title | Hydration Patterns in Sodium Alginate Polymeric Matrix Tablets The Result of Drug Substance Incorporation | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 715532 | - |
dc.date.updated | 2021-11-25T10:57:05Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) |
Files in This Item:
File | Description | Size | Format | |
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715532.pdf | 1.42 MB | Adobe PDF | View/Open |
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