Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/181618
Title: | Polymeric Nanoparticles and Chitosan Gel Loading Ketorolac Tromethamine to Alleviate Pain Associated with Condyloma Acuminata during the Pre- and Post-Ablation |
Author: | El Moussaoui, Salima Abo-Horan, Ismael Halbaut, Lyda Alonso, Cristina Coderch Negra, Ma. Luisa Garduño Ramírez, María Luisa del Carmen Clares Naveros, Beatriz Soriano-Ruiz, José L. Calpena Campmany, Ana Cristina Fernández Campos, Francisco Mallandrich Miret, Mireia |
Keywords: | Papil·lomavirus Malalties infeccioses Agents antiinflamatoris Nanomedicina Papillomaviruses Communicable diseases Antiinflammatory agents Nanomedicine |
Issue Date: | 25-Oct-2021 |
Publisher: | MDPI |
Abstract: | This study describes the preparation and evaluation of two formulations, a hydrogel and a nanostructured system, containing ketorolac tromethamine as an anti-inflammatory agent for the local therapy against the inflammatory process derived from the surgical excision of Condyloma acuminata. Both formulations were physicochemically characterized. In vitro release profiles show that the nanoparticles release 92% ± 2.3 of the total ketorolac tromethamine encapsulated, while the chitosan gel releases 18.6% ± 0.2. The ex vivo permeation and distribution through human skin were also assayed and was observed how the main amount of ketorolac tromethamine is retained in the epidermis. In vivo studies were accomplished to evaluate the anti-inflammatory efficacy in mice which also involved the histological analysis to confirm the in vivo results. The nanoparticles present a significantly higher anti-inflammatory efficacy than chitosan gel. The tolerability of developed formulations was assessed by monitoring the biomechanical properties of the skin before and after application of both formulations. No statistical differences in trans-epidermal water loss and skin hydration with respect to the basal values were observed and the formulations exhibited higher anti-inflammatory activity compared to a reference ketotorlac tromethamine solution. Therefore, it can be concluded that both formulations can be proposed as outstanding candidates for offering a local anti-inflammatory therapeutical tool with potential clinical applica |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/pharmaceutics13111784 |
It is part of: | Pharmaceutics, 2021, vol. 13, num. 11, p. 1784 |
URI: | http://hdl.handle.net/2445/181618 |
Related resource: | https://doi.org/10.3390/pharmaceutics13111784 |
ISSN: | 1999-4923 |
Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
715601.pdf | 1.94 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License