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Title: Chronic liquid fructose supplementation does not cause liver tumorigenesis but elicits clear sex differences in the metabolic response in Sprague-Dawley rats
Author: Roglans i Ribas, Núria
Baena Muñoz, Miguel
Sangüesa Puigventós, Gemma
Velázquez, Ana Magdalena
Griñán Ferré, Christian
Pallàs i Llibería, Mercè, 1964-
Sánchez Peñarroya, Rosa M.
Alegret i Jordà, Marta
Laguna Egea, Juan Carlos
Keywords: Càncer de fetge
Malalties del fetge
Àcids grassos
Síndrome metabòlica
Liver cancer
Liver diseases
Fatty acids
Metabolic syndrome
Issue Date: 22-Sep-2021
Publisher: Swedish Nutrition Foundation
Abstract: Background: Non-alcoholic fatty liver disease (NAFLD) has increased over the last decades and may evolve into hepatocellular carcinoma (HCC). As HCC is challenging to treat, knowledge on the modifiable risk factors for NAFLD/HCC (e.g. hyper caloric diets rich in fructose) is essential. Objective and design: We used a model of diethyl nitrosamine-induced hepatocarcinogenesis to investigate the liver cancer-promoting effects of a diet supplemented with 10% liquid fructose, administered to male and female rats for 11 months. A subset of the fructose-supplemented rats received resveratrol (RVT) in the last 4 months of treatment. Results and discussion: Rat livers showed no de visu or histological evidence of liver tumorigenesis. However, we observed metabolic abnormalities that could be related to cancer development mainly in the female fructose-supplemented rats, such as increases in weight, adiposity and hepatic triglyceride levels, as well as hyperglycaemia, hyperuricemia, hyperleptinemia and a reduced insulin sensitivity index, which were partially reversed by RVT. Therefore, we performed a targeted analysis of 84 cancer-related genes in the female liver samples, which revealed expression changes associated with cancer-related pathways. Analysis of individual genes indicated that some changes increased the risk of hepatocarcinogenesis (Sfrp2, Ccl5, Socs3, and Gstp1), while others exerted a protective/preventive effect (Bcl2 and Cdh1). Conclusion: Our data clearly demonstrate that chronic fructose supplementation, as the sole dietary intervention, does not cause HCC development in rats. Keywords: diethyl nitrosamine; hepatocellular cancer; metabolic syndrome; sugar-sweetened beverages; sugary drinks.
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It is part of: Food & Nutrition Research, 2021, vol. 65, p. 7670
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ISSN: 1654-6628
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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