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Title: Thymol-loaded PLGA nanoparticles: an efficient approach for acne treatment
Author: Folle, Camila
Marqués Villavecchia, Ana M.
Díaz-Garrido, Natalia
Espina García, Marta
Sánchez López, E. (Elena)
Badía Palacín, Josefa
Baldomà Llavinés, Laura
Calpena Campmany, Ana Cristina
García López, María Luisa
Keywords: Acne
Malalties de la pell
Sistemes d'alliberament de medicaments
Skin diseases
Drug delivery systems
Issue Date: 8-Nov-2021
Publisher: BioMed Central
Abstract: Abstract Background: Acne is a common skin disorder that involves an infection inside the hair follicle, which is usually treated with antibiotics, resulting in unbalanced skin microbiota and microbial resistance. For this reason, we devel‑ oped polymeric nanoparticles encapsulating thymol, a natural active compound with antimicrobial and antioxidant properties. In this work, optimization physicochemical characterization, biopharmaceutical behavior and therapeutic efficacy of this novel nanostructured system were assessed. Results: Thymol NPs (TH‑NP) resulted on suitable average particle size below 200 nm with a surface charge around − 28 mV and high encapsulation efficiency (80%). TH‑NP released TH in a sustained manner and provide a slow‑rate penetration into the hair follicle, being highly retained inside the skin. TH‑NP possess a potent antimicrobial activity against Cutibacterium acnes and minor effect towards Staphylococcus epidermis, the major resident of the healthy skin microbiota. Additionally, the stability and sterility of developed NPs were maintained along storage. Conclusion: TH‑NP showed a promising and efficient alternative for the treatment of skin acne infection, avoid‑ ing antibiotic administration, reducing side effects, and preventing microbial drug resistance, without altering the healthy skin microbiota. Additionally, TH‑NP enhanced TH antioxidant activity, constituting a natural, preservative‑free, approach for acne treatment
Note: Reproducció del document publicat a:
It is part of: Journal of Nanobiotechnology, 2021, vol. 19, num. 359, p. 1-21
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ISSN: 1477-3155
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)

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