Please use this identifier to cite or link to this item:
Title: Extracellular matrix remodeling in chronic liver disease
Author: Ortiz, Cristina
Schierwagen, Robert
Schaefer, Liliana
Klein, Sabine
Trepat Guixer, Xavier
Trebicka, Jonel
Keywords: Malalties del fetge
Medicina regenerativa
Liver diseases
Regenerative medicine
Issue Date: 23-Jul-2021
Abstract: This review aims to summarize the current knowledge of the extracellular matrix remodeling during hepatic fibrosis. We discuss the diverse interactions of the extracellular matrix with hepatic cells and the surrounding matrix in liver fibrosis, with the focus on the molecular pathways and the mechanisms that regulate extracellular matrix remodeling. Recent Findings The extracellular matrix not only provides structure and support for the cells, but also controls cell behavior by providing adhesion signals and by acting as a reservoir of growth factors and cytokines. Summary Hepatic fibrosis is characterized by an excessive accumulation of extracellular matrix. During fibrogenesis, the natural remodeling process of the extracellular matrix varies, resulting in the excessive accumulation of its components, mainly collagens. Signals released by the extracellular matrix induce the activation of hepatic stellate cells, which are the major source of extracellular matrix and most abundant myofibroblasts in the liver. Graphical abstract
Note: Reproducció del document publicat a:
It is part of: Current Tissue Microenvironment Reports, 2021, vol. 2, p. 41-52
Related resource:
ISSN: 2662-4079
Appears in Collections:Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

Files in This Item:
File Description SizeFormat 
12537_6530387_ortiz2021_article_extracellularmatrixremodelingi.pdf2.27 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons