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http://hdl.handle.net/2445/181680
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DC Field | Value | Language |
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dc.contributor.author | Fuentes, Pedro | - |
dc.contributor.author | Pelletier, Joffrey | - |
dc.contributor.author | Martinez Herráez, Carolina | - |
dc.contributor.author | Diez Obrero, Virginia | - |
dc.contributor.author | Iannizzotto, Flavia | - |
dc.contributor.author | Rubio, Teresa | - |
dc.contributor.author | Garcia Cajide, Marta | - |
dc.contributor.author | Menoyo, Sandra | - |
dc.contributor.author | Moreno Aguado, Víctor | - |
dc.contributor.author | Salazar, Ramón | - |
dc.contributor.author | Tauler Girona, Albert | - |
dc.contributor.author | Gentilella, Antonio | - |
dc.date.accessioned | 2021-12-09T13:28:36Z | - |
dc.date.available | 2021-12-09T13:28:36Z | - |
dc.date.issued | 2021-11-26 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | http://hdl.handle.net/2445/181680 | - |
dc.description.abstract | Ribosomes execute the transcriptional program in every cell. Critical to sustain nearly all cellular activities, ribosome biogenesis requires the translation of ~200 factors of which 80 are ribosomal proteins (RPs). As ribosome synthesis depends on RP mRNA translation, a priority within the translatome architecture should exist to ensure the preservation of ribosome biogenesis capacity, particularly under adverse growth conditions. Here, we show that under critical metabolic constraints characterized by mTOR inhibition, LARP1 complexed with the 40S subunit protects from ribophagy the mRNAs regulon for ribosome biogenesis and protein synthesis, acutely preparing the translatome to promptly resume ribosomes production after growth conditions return permissive. Characterizing the LARP1-protected translatome revealed a set of 5′TOP transcript isoforms other than RPs involved in energy production and in mitochondrial function, among other processes, indicating that the mTOR-LARP1-5′TOP axis acts at the translational level as a primary guardian of the cellular anabolic capacity. | - |
dc.format.extent | 16 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Association for the Advancement of Science (AAAS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1126/sciadv.abg9275 | - |
dc.relation.ispartof | Science Advances, 2021, vol. 7, num. 48 | - |
dc.relation.uri | https://doi.org/10.1126/sciadv.abg9275 | - |
dc.rights | cc by-nc (c) Fuentes, Pedro et al, 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Ribosomes | - |
dc.subject.classification | Síntesi proteica | - |
dc.subject.other | Ribosomes | - |
dc.subject.other | Protein synthesis | - |
dc.title | The 40 S -LARP1 complex reprograms the cellular translatome upon mTOR inhibition to preserve the protein synthetic capacity | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-12-02T08:46:46Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34818049 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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sciadv.abg9275.pdf | 1.46 MB | Adobe PDF | View/Open |
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