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Title: NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery
Author: Hueso Val, Miguel
Mallén, Adrián
Suñé Pou, Marc
Aran Perramon, Josep M.
Suñé i Negre, Josep M. (Josep Maria)
Navarro, Estanis
Keywords: Nanomedicina
Àcids nucleics
Nucleic acids
Issue Date: 27-Oct-2021
Publisher: MDPI AG
Abstract: Non-coding RNAs (ncRNAs) are emerging therapeutic tools but there are barriers to their translation to clinical practice. Key issues concern the specificity of the targets, the delivery of the molecules, and their stability, while avoiding "on-target" and "off-target" side effects. In this "ncRNA in therapeutics" issue, we collect several studies of the differential expression of ncRNAs in cardiovascular diseases, bone metabolism-related disorders, neurology, and oncology, and their potential to be used as biomarkers or therapeutic targets. Moreover, we review recent advances in the use of antisense ncRNAs in targeted therapies with a particular emphasis on their basic biological mechanisms, their translational potential, and future trends.
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It is part of: International Journal of Molecular Sciences, 2021, vol. 22, num. 21, p. 11596
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ISSN: 1422-0067
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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