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http://hdl.handle.net/2445/181697| Title: | NcRNAs in Therapeutics: Challenges and Limitations in Nucleic Acid-Based Drug Delivery |
| Author: | Hueso Val, Miguel Mallén, Adrián Suñé Pou, Marc Aran Perramon, Josep M. Suñé i Negre, Josep M. (Josep Maria) Navarro, Estanis |
| Keywords: | Nanomedicina Àcids nucleics Nanomedicine Nucleic acids |
| Issue Date: | 27-Oct-2021 |
| Publisher: | MDPI AG |
| Abstract: | Non-coding RNAs (ncRNAs) are emerging therapeutic tools but there are barriers to their translation to clinical practice. Key issues concern the specificity of the targets, the delivery of the molecules, and their stability, while avoiding "on-target" and "off-target" side effects. In this "ncRNA in therapeutics" issue, we collect several studies of the differential expression of ncRNAs in cardiovascular diseases, bone metabolism-related disorders, neurology, and oncology, and their potential to be used as biomarkers or therapeutic targets. Moreover, we review recent advances in the use of antisense ncRNAs in targeted therapies with a particular emphasis on their basic biological mechanisms, their translational potential, and future trends. |
| Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijms222111596 |
| It is part of: | International Journal of Molecular Sciences, 2021, vol. 22, num. 21, p. 11596 |
| URI: | http://hdl.handle.net/2445/181697 |
| Related resource: | https://doi.org/10.3390/ijms222111596 |
| ISSN: | 1422-0067 |
| Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| ijms-22-11596-v2.pdf | 6.68 MB | Adobe PDF | View/Open |
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