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DC Field | Value | Language |
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dc.contributor.author | Garcia Sangenís, Ana | - |
dc.contributor.author | Morros Pedrós, Rosa | - |
dc.contributor.author | Aguilar Sánchez, Mercedes | - |
dc.contributor.author | Medina Perucha, Laura | - |
dc.contributor.author | Leiva, Alfonso | - |
dc.contributor.author | Ripoll, Joana | - |
dc.contributor.author | Martínez Pecharromán, Mar | - |
dc.contributor.author | Bartolomé Moreno, Cruz B | - |
dc.contributor.author | Magallon Botaya, Rosa | - |
dc.contributor.author | Marín Cañada, Jaime | - |
dc.contributor.author | Molero, José M. | - |
dc.contributor.author | Moragas, Ana | - |
dc.contributor.author | Troncoso, Amelia | - |
dc.contributor.author | Monfà, Ramon | - |
dc.contributor.author | Llor, Carl | - |
dc.date.accessioned | 2021-12-13T11:52:34Z | - |
dc.date.available | 2021-12-13T11:52:34Z | - |
dc.date.issued | 2021-11-01 | - |
dc.identifier.issn | 2044-6055 | - |
dc.identifier.uri | http://hdl.handle.net/2445/181799 | - |
dc.description.abstract | Introduction: Uncomplicated lower urinary tract infections (uLUTI) are a common problem in primary care. Current local guidelines recommend the use of a single 3 g dose of fosfomycin. However, most general practitioners (GP) prefer short-course therapies to single-dose therapy. No study has compared head-to-head short-course antimicrobial agents for uLUTIs. Therefore, the aim of this randomised clinical trial is to compare three different short-course antibiotic therapies with a single-dose of fosfomycin for these infections. Methods and analysis: This will be a pragmatic, multicentre, parallel group, open trial. Women aged 18 or older and with symptoms of uLUTI and a positive urine dipstick analysis will be randomised to one of the following four groups: a single dose of 3 g of fosfomycin, 2 days of 3 g of fosfomycin o.d., 3 days of pivmecillinam 400 mg three times per day (t.i.d) or 5 days of nitrofurantoin 100 mg t.i.d. A total sample of 1120 patients was calculated. The primary endpoint is clinical effectiveness at day 7, defined as cure of symptoms reported by the patients in a diary including four symptoms: dysuria, urgency, frequency and suprapubic pain, which will be scored on a 4-point severity scale (not present/mild/moderate/severe). Follow-up visits are scheduled at days 7 (phone call), 14 and 28 for assessing evolution. Urine samples will be collected in the three on-site visits and urine cultures performed. If positive, antibiograms for the three antibiotics studied will be performed. Bacterial eradication will be measured at days 14 and 28. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BMJ | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1136/bmjopen-2021-055898 | - |
dc.relation.ispartof | BMJ Open, 2021, vol. 11, num. 11 | - |
dc.relation.uri | https://doi.org/10.1136/bmjopen-2021-055898 | - |
dc.rights | cc by-nc (c) Garcia Sangenís, Ana et al, 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Infeccions del tracte urinari | - |
dc.subject.classification | Terapèutica | - |
dc.subject.classification | Antibiòtics | - |
dc.subject.other | Urinary tract infections | - |
dc.subject.other | Therapeutics | - |
dc.subject.other | Antibiotics | - |
dc.title | Clinical effectiveness and bacteriological eradication of three different Short-COurse antibiotic regimens and single-dose fosfomycin for uncomplicated lower Urinary Tract infections in adult women (SCOUT study): study protocol for a randomised clinical trial | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-12-10T08:11:31Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34824124 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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