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http://hdl.handle.net/2445/181864
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DC Field | Value | Language |
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dc.contributor.author | Berenguer, Juan | - |
dc.contributor.author | Díez, Cristina | - |
dc.contributor.author | Martín Vicente, María | - |
dc.contributor.author | Micán, Rafael | - |
dc.contributor.author | Pérez Elías, María Jesús | - |
dc.contributor.author | García Fraile, Lucio J. | - |
dc.contributor.author | Vidal, Francisco | - |
dc.contributor.author | Suárez García, Inés | - |
dc.contributor.author | Podzamczer Palter, Daniel | - |
dc.contributor.author | Romero, Jorge del | - |
dc.contributor.author | Pulido, Federico | - |
dc.contributor.author | Iribarren, José A. | - |
dc.contributor.author | Gutiérrez, Félix | - |
dc.contributor.author | Poveda, Eva | - |
dc.contributor.author | Galera, Carlos | - |
dc.contributor.author | Izquierdo, Rebeca | - |
dc.contributor.author | Asensi, Victor | - |
dc.contributor.author | Portilla, Joaquín | - |
dc.contributor.author | López, Juan C. | - |
dc.contributor.author | Arribas, José Ramón | - |
dc.contributor.author | Moreno, Santiago | - |
dc.contributor.author | González García, Juan | - |
dc.contributor.author | Resino, Salvador | - |
dc.contributor.author | Jarrín, Inmaculada | - |
dc.date.accessioned | 2021-12-16T18:08:47Z | - |
dc.date.available | 2021-12-16T18:08:47Z | - |
dc.date.issued | 2021-06-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/181864 | - |
dc.description.abstract | Objectives: We aimed to assess the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and factors associated with seropositivity and asymptomatic coronavirus disease 2019 (COVID-19) among people with HIV (PWH). Methods: This was a cross-sectional study carried out within the cohort of the Spanish HIV Research Network. Participants were consecutive PWH with plasma collected from 1st April to 30th September 2020. We determined SARS-CoV-2 antibodies (Abs) in plasma. Illness severity (NIH criteria) was assessed by a review of medical records and, if needed, participant interviews. Multivariable logistic regression analysis was used to identify predictors of seropositivity among the following variables: sex, age, country of birth, education level, comorbidities (hypertension, chronic heart disease, diabetes mellitus, non-AIDS-related cancer, chronic kidney disease, cirrhosis), route of HIV acquisition, prior AIDS, CD4+ cell count, HIV viral load, nucleoside/nucleotide reverse transcriptase inhibitor (N [t]RTI) backbone, type of third antiretroviral drug, and month of sample collection. Results: Of 1076 PWH (88.0% males, median age 43 years, 97.7% on antiretroviral therapy, median CD4+ 688 cells/mm3, 91.4% undetectable HIV viral load), SARS-CoV-2 Abs were detected in 91 PWH, a seroprevalence of 8.5% (95%CI 6.9-10.3%). Forty-five infections (45.0%) were asymptomatic. Variables independently associated with SARS-CoV-2 seropositivity were birth in Latin American countries versus Spain (adjusted odds ratio (aOR) 2.30, 95%CI 1.41-3.76, p 0.001), and therapy with tenofovir disoproxil fumarate plus emtricitabine (TDF/FTC) versus tenofovir alafenamide (TAF)/FTC as the N(t)RTI backbone (aOR 0.49, 95%CI 0.26-0.94, p 0.031). Conclusions: Many SARS-CoV-2 infections among PWH were asymptomatic, and birth in Latin American countries increased the risk of SARS-CoV-2 seropositivity. Our analysis, adjusted by comorbidities and other variables, suggests that TDF/FTC may prevent SARS-CoV-2 infection among PWH. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.cmi.2021.06.023 | - |
dc.relation.ispartof | Clinical Microbiology and Infection, 2021, vol. 27, núm. 11, p. 1678-1684 | - |
dc.relation.uri | https://doi.org/10.1016/j.cmi.2021.06.023 | - |
dc.rights | cc by-nc-nd (c) Berenguer, Juan et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | SARS-CoV-2 | - |
dc.subject.classification | COVID-19 | - |
dc.subject.classification | VIH (Virus) | - |
dc.subject.classification | Serodiagnòstic | - |
dc.subject.other | SARS-CoV-2 | - |
dc.subject.other | COVID-19 | - |
dc.subject.other | HIV (Viruses) | - |
dc.subject.other | Serodiagnosis | - |
dc.title | Prevalence and factors associated with SARS-CoV-2 seropositivity in the Spanish HIV Research Network Cohort | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-12-16T09:06:24Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34186209 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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