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http://hdl.handle.net/2445/182014
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DC Field | Value | Language |
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dc.contributor.author | Castaño Linares, Óscar | - |
dc.contributor.author | López Mengual, Ana | - |
dc.contributor.author | Reginensi, Diego | - |
dc.contributor.author | Matamoros i Anglès, Andreu | - |
dc.contributor.author | Engel, Elisabeth | - |
dc.contributor.author | Río Fernández, José Antonio del | - |
dc.date.accessioned | 2021-12-23T16:37:26Z | - |
dc.date.available | 2021-12-23T16:37:26Z | - |
dc.date.issued | 2021-03-22 | - |
dc.identifier.issn | 2296-4185 | - |
dc.identifier.uri | http://hdl.handle.net/2445/182014 | - |
dc.description.abstract | Following spinal cord injury, olfactory ensheathing cell (OEC) transplantation is a promising therapeutic approach in promoting functional improvement. Some studies report that the migratory properties of OECs are compromised by inhibitory molecules and potentiated by chemical concentration differences. Here we compare the attachment, morphology, and directionality of an OEC-derived cell line, TEG3 cells, seeded on functionalized nanoscale meshes of Poly(l/dl-lactic acid; PLA) nanofibers. The size of the nanofibers has a strong effect on TEG3 cell adhesion and migration, with the PLA nanofibers having a 950 nm diameter being the ones that show the best results. TEG3 cells are capable of adopting a bipolar morphology on 950 nm fiber surfaces, as well as a highly dynamic behavior in migratory terms. Finally, we observe that functionalized nanofibers, with a chemical concentration increment of SDF-1α/CXCL12, strongly enhance the migratory characteristics of TEG3 cells over inhibitory substrates. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fbioe.2021.627805 | - |
dc.relation.ispartof | Frontiers In Bioengineering And Biotechnology, 2021, vol. 9 | - |
dc.relation.uri | https://doi.org/10.3389/fbioe.2021.627805 | - |
dc.rights | cc-by (c) Castano, Oscar et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Enginyeria Electrònica i Biomèdica) | - |
dc.subject.classification | Lesions medul·lars | - |
dc.subject.classification | Teràpia cel·lular | - |
dc.subject.other | Spinal cord injuries | - |
dc.subject.other | Cellular therapy | - |
dc.title | Chemotactic TEG3 Cells' Guiding Platforms Based on PLA Fibers Functionalized With the SDF-1 alpha/CXCL12 Chemokine for Neural Regeneration Therapy | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 713652 | - |
dc.date.updated | 2021-12-23T16:37:26Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 6492007 | - |
dc.identifier.pmid | 33829009 | - |
Appears in Collections: | Articles publicats en revistes (Enginyeria Electrònica i Biomèdica) Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
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713652.pdf | 3.95 MB | Adobe PDF | View/Open |
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