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Title: Engineering transient dynamics of artificial cells by stochastic distribution of enzymes
Author: Song, Shidong
Mason, Alexander F.
Post, Richard A. J.
Corato, Marco de
Mestre, Rafael
Yewdall, Amy N.
Cao, Shoupeng
Hofstad, Remco W. van der
Sánchez Ordóñez, Samuel
Abdelmohsen, Loai K. E. A.
Hest, Jan C. M. van
Keywords: Processos estocàstics
Stochastic processes
Issue Date: 25-Nov-2021
Publisher: Nature Research
Abstract: Random fluctuations are inherent to all complex molecular systems. Although nature has evolved mechanisms to control stochastic events to achieve the desired biological output, reproducing this in synthetic systems represents a significant challenge. Here we present an artificial platform that enables us to exploit stochasticity to direct motile behavior. We found that enzymes, when confined to the fluidic polymer membrane of a core-shell coacervate, were distributed stochastically in time and space. This resulted in a transient, asymmetric configuration of propulsive units, which imparted motility to such coacervates in presence of substrate. This mechanism was confirmed by stochastic modelling and simulations in silico. Furthermore, we showed that a deeper understanding of the mechanism of stochasticity could be utilized to modulate the motion output. Conceptually, this work represents a leap in design philosophy in the construction of synthetic systems with life-like behaviors.
Note: Reproducció del document publicat a:
It is part of: Nature Communications, 2021, vol. 12
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ISSN: 2041-1723
Appears in Collections:Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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