Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/182364
Title: Mfn2 localization in the ER is necessary for its bioenergetic function and neuritic development
Author: Casellas Díaz, Sergi
Larramona-Arcas, Raquel
Riqué-Pujol, Guillem
Tena-Morraja, Paula
Müller Sánchez, Claudia Alejandra
Segarra-Mondejar, Marc
Gavaldà i Navarro, Aleix
Villarroya i Gombau, Francesc
Reina del Pozo, Manuel
Martínez Estrada, Ofelia María
Soriano Zaragoza, Francesc X. (Francesc Xavier)
Keywords: Mitocondris
Proteïnes
Metabolisme energètic
Trastorns del metabolisme
Fisiologia patològica
Mitochondria
Proteins
Energy metabolism
Disorders of metabolism
Pathological physiology
Issue Date: 6-Sep-2021
Publisher: EMBO Press
Abstract: Mfn2 is a mitochondrial fusion protein with bioenergetic functionsimplicated in the pathophysiology of neuronal and metabolicdisorders. Understanding the bioenergetic mechanism of Mfn2may aid in designing therapeutic approaches for these disorders.Here we show using endoplasmic reticulum (ER) or mitochondria-targeted Mfn2 that Mfn2 stimulation of the mitochondrial meta-bolism requires its localization in the ER, which is independent ofits fusion function. ER-located Mfn2 interacts with mitochondrialMfn1/2 to tether the ER and mitochondria together, allowing Ca2+transfer from the ER to mitochondria to enhance mitochondrialbioenergetics. The physiological relevance of these findings isshown during neurite outgrowth, when there is an increase inMfn2-dependent ER-mitochondria contact that is necessary forcorrect neuronal arbor growth. Reduced neuritic growth in Mfn2KO neurons is recovered by the expression of ER-targeted Mfn2 oran artificial ER-mitochondria tether, indicating that manipulationof ER-mitochondria contacts could be used to treat pathologicconditions involving Mfn2.
Note: Reproducció del document publicat a: https://doi.org/10.15252/embr.202051954
It is part of: EMBO Reports, 2021, vol. 22, num. 9, p. 1-20
URI: http://hdl.handle.net/2445/182364
Related resource: https://doi.org/10.15252/embr.202051954
ISSN: 1469-221X
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Files in This Item:
File Description SizeFormat 
714193.pdf1.3 MBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons