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http://hdl.handle.net/2445/182648
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DC Field | Value | Language |
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dc.contributor.author | Andreu-Bernabeu, Álvaro | - |
dc.contributor.author | Díaz-Caneja, Covadonga M. | - |
dc.contributor.author | Costas, Javier | - |
dc.contributor.author | De Hoyos, Lucía | - |
dc.contributor.author | Stella, Carol | - |
dc.contributor.author | Gurriarán, Xaquín | - |
dc.contributor.author | Alloza, Clara | - |
dc.contributor.author | Fañanás Saura, Lourdes | - |
dc.contributor.author | Bobes García, Julio | - |
dc.contributor.author | González-Pinto, Ana | - |
dc.contributor.author | Crespo-Facorro, Benedicto | - |
dc.contributor.author | Martorell, Lourdes | - |
dc.contributor.author | Vilella, Elisabet | - |
dc.contributor.author | Muntané, Gerard | - |
dc.contributor.author | Nacher, Juan | - |
dc.contributor.author | Moltó, M. Dolors | - |
dc.contributor.author | Aguilar, Eduardo Jesús | - |
dc.contributor.author | Parellada, Mara | - |
dc.contributor.author | Arango López, Celso | - |
dc.contributor.author | González-Peñas, Javier | - |
dc.date.accessioned | 2022-01-25T17:50:46Z | - |
dc.date.available | 2022-01-25T17:50:46Z | - |
dc.date.issued | 2022-01-10 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2445/182648 | - |
dc.description.abstract | Previous research suggests an association of loneliness and social isolation (LNL-ISO) with schizophrenia. Here, we demonstrate a LNL-ISO polygenic score contribution to schizophrenia risk in an independent case-control sample (N = 3,488). We then subset schizophrenia predisposing variation based on its effect on LNL-ISO. We find that genetic variation with concordant effects in both phenotypes shows significant SNP-based heritability enrichment, higher polygenic contribution in females, and positive covariance with mental disorders such as depression, anxiety, attention-deficit hyperactivity disorder, alcohol dependence, and autism. Conversely, genetic variation with discordant effects only contributes to schizophrenia risk in males and is negatively correlated with those disorders. Mendelian randomization analyses demonstrate a plausible bi-directional causal relationship between LNL-ISO and schizophrenia, with a greater effect of LNL-ISO liability on schizophrenia than vice versa. These results illustrate the genetic footprint of LNL-ISO on schizophrenia. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41467-021-27598-6 | - |
dc.relation.ispartof | Nature Communications, 2022, vol. 13, num. 51, p. 1-11 | - |
dc.relation.uri | https://doi.org/10.1038/s41467-021-27598-6 | - |
dc.rights | cc-by (c) Andreu-Bernabeu, Álvaro et al., 2022 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals) | - |
dc.subject.classification | Aïllament social | - |
dc.subject.classification | Esquizofrènia | - |
dc.subject.classification | Lleis de Mendel | - |
dc.subject.classification | Dones | - |
dc.subject.classification | Homes | - |
dc.subject.other | Social isolation | - |
dc.subject.other | Schizophrenia | - |
dc.subject.other | Mendel's law | - |
dc.subject.other | Women | - |
dc.subject.other | Men | - |
dc.title | Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 717537 | - |
dc.date.updated | 2022-01-25T17:50:46Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/603196/EU//PSYSCAN | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/602478/EU//METSY | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/777394/EU//AIMS-2-TRIALS | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/115916/EU//PRISM | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/241909/EU//EU-GEI | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals) Publicacions de projectes de recerca finançats per la UE |
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717537.pdf | 1.06 MB | Adobe PDF | View/Open |
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