Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/182679
Title: | Altered structural brain asymmetry in autism spectrum disorder in a study of 54 datasets |
Author: | Postema, Merel C. van Rooij, Daan Anagnostou, Evdokia Arango, Celso Auzias, Guillaume Behrmann, Marlene Filho, Geraldo Busatto Calderoni, Sara Calvo Escalona, Rosa Daly, Eileen Deruelle, Christine Di Martino, Adriana Dinstein, Illan Duran, Fabio Luis S. Durston, Sarah Ecker, Christine Ehrlich, Stefan Fair, Damien Fedor, Jennifer Feng, Xin FitzGerald, Jackie Floris, Dorothea L. Freitag, Christine M. Gallagher, Louise Glahn, David C. Gori, Ilaria Haar, Shlomi Hoekstra, Liesbeth Jahanshad, Neda Jalbrzikowski, Maria Janssen, Joost King, Joseph A. Kong, Xiang-Zhen Lazaro, Luisa Lerch, Jason P. Luna, Beatriz Martinho, Mauricio M. McGrath, Jane Medland, Sarah E. Muratori, Filippo |
Keywords: | Autisme Neurociències Autism Neurosciences |
Issue Date: | 31-Oct-2019 |
Publisher: | Nature Publishing Group |
Abstract: | Altered structural brain asymmetry in autism spectrum disorder (ASD) has been reported. However, findings have been inconsistent, likely due to limited sample sizes. Here we investigated 1,774 individuals with ASD and 1,809 controls, from 54 independent data sets of the ENIGMA consortium. ASD was significantly associated with alterations of cortical thickness asymmetry in mostly medial frontal, orbitofrontal, cingulate and inferior temporal areas, and also with asymmetry of orbitofrontal surface area. These differences generally involved reduced asymmetry in individuals with ASD compared to controls. Furthermore, putamen volume asymmetry was significantly increased in ASD. The largest case-control effect size was Cohen's d = -0.13, for asymmetry of superior frontal cortical thickness. Most effects did not depend on age, sex, IQ, severity or medication use. Altered lateralized neurodevelopment may therefore be a feature of ASD, affecting widespread brain regions with diverse functions. Large-scale analysis was necessary to quantify subtle alterations of brain structural asymmetry in ASD. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41467-019-13005-8 |
It is part of: | Nature Communications, 2019, vol. 10, num. 1, p. 4958 |
URI: | http://hdl.handle.net/2445/182679 |
Related resource: | https://doi.org/10.1038/s41467-019-13005-8 |
ISSN: | 2041-1723 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) Publicacions de projectes de recerca finançats per la UE |
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