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http://hdl.handle.net/2445/182728
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DC Field | Value | Language |
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dc.contributor.author | Remuzgo Martínez, Sara | - |
dc.contributor.author | Atienza Mateo, Belén | - |
dc.contributor.author | Ocejo Vinyals, J. Gonzalo | - |
dc.contributor.author | Genre, Fernanda | - |
dc.contributor.author | Pulito Cueto, Verónica | - |
dc.contributor.author | Mora Cuesta, Víctor M. | - |
dc.contributor.author | Iturbe Fernández, David | - |
dc.contributor.author | Lera Gómez, Leticia | - |
dc.contributor.author | Pérez Fernández, Raquel | - |
dc.contributor.author | Prieto Peña, Diana | - |
dc.contributor.author | Irure, Juan | - |
dc.contributor.author | Romero Bueno, Fredeswinda | - |
dc.contributor.author | Sanchez Pernaute, Olga | - |
dc.contributor.author | Alonso Moralejo, Rodrigo | - |
dc.contributor.author | Nuño, Laura | - |
dc.contributor.author | Bonilla, Gema | - |
dc.contributor.author | Vicente Rabaneda, Esther F. | - |
dc.contributor.author | Grafia, Ignacio | - |
dc.contributor.author | Prieto González, Sergio | - |
dc.contributor.author | Narváez, Javier | - |
dc.contributor.author | Trallero Araguas, Ernesto | - |
dc.contributor.author | Selva O’Callaghan, Albert | - |
dc.contributor.author | Ortego Centeno, Norberto | - |
dc.contributor.author | Pérez Gómez, Nair | - |
dc.contributor.author | Mera, Antonio | - |
dc.contributor.author | Martínez Barrio, Julia | - |
dc.contributor.author | Moriano, Clara | - |
dc.contributor.author | Díez, Elvira | - |
dc.contributor.author | Calvo Alén, Jaime | - |
dc.contributor.author | Balsa, Alejandro | - |
dc.contributor.author | Ussetti, María Piedad | - |
dc.contributor.author | Laporta, Rosalía | - |
dc.contributor.author | Berastegui, Cristina | - |
dc.contributor.author | Solé, Amparo | - |
dc.contributor.author | Gualillo, Oreste | - |
dc.contributor.author | Cavagna, Lorenzo | - |
dc.contributor.author | Cifrián, José M. | - |
dc.contributor.author | Renzoni, Elisabetta A. | - |
dc.contributor.author | Castañeda, Santos | - |
dc.contributor.author | López Mejías, Raquel | - |
dc.contributor.author | González Gay, Miguel A. | - |
dc.contributor.author | Spanish Biomarkers Of Antisynthetase Syndrome Consortium | - |
dc.contributor.author | Spanish Biomarkers Of Interstitial Lung Disease Consortium | - |
dc.date.accessioned | 2022-01-27T16:53:31Z | - |
dc.date.available | 2022-01-27T16:53:31Z | - |
dc.date.issued | 2021-11-19 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/182728 | - |
dc.description.abstract | Mucin 1/Krebs von den Lungen-6 (KL-6) is proposed as a serum biomarker of several interstitial lung diseases (ILDs), including connective tissue disorders associated with ILD. However, it has not been studied in a large cohort of Caucasian antisynthetase syndrome (ASSD) patients. Consequently, we assessed the role of MUC1 rs4072037 and serum KL-6 levels as a potential biomarker of ASSD susceptibility and for the differential diagnosis between patients with ILD associated with ASSD (ASSD-ILD +) and idiopathic pulmonary fibrosis (IPF). 168 ASSD patients (149 ASSD-ILD +), 174 IPF patients and 523 healthy controls were genotyped for MUC1 rs4072037 T > C. Serum KL-6 levels were determined in a subgroup of individuals. A significant increase of MUC1 rs4072037 CC genotype and C allele frequencies was observed in ASSD patients compared to healthy controls. Likewise, MUC1 rs4072037 TC and CC genotypes and C allele frequencies were significantly different between ASSD-ILD+ and IPF patients. Additionally, serum KL-6 levels were significantly higher in ASSD patients compared to healthy controls. Nevertheless, no differences in serum KL-6 levels were found between ASSD-ILD+ and IPF patients. Our results suggest that the presence of MUC1 rs4072037 C allele increases the risk of ASSD and it could be a useful genetic biomarker for the differential diagnosis between ASSD-ILD+ and IPF patients. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Science and Business Media LLC | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-021-01992-y | - |
dc.relation.ispartof | Scientific Reports, 2021, vol 11, num 1 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-021-01992-y | - |
dc.rights | cc by (c) Remuzgo Martínez, Sara et al, 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Fibrosi pulmonar | - |
dc.subject.classification | Genètica mèdica | - |
dc.subject.other | Pulmonary fibrosis | - |
dc.subject.other | Medical genetics | - |
dc.title | Role of MUC1 rs4072037 polymorphism and serum KL-6 levels in patients with antisynthetase syndrome | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-01-25T12:51:10Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/734899/EU//Olive-Net | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34799647 | - |
Appears in Collections: | Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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s41598-021-01992-y.pdf | 1.22 MB | Adobe PDF | View/Open |
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