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Title: Dietary Intake of Advanced Glycation End Products (AGEs) and Mortality Among Individuals with Colorectal Cancer
Author: Mao, Ziling
Aglago, Elom K.
Zhao, Zhiwei
Schalkwijk, Casper
Li, Li
Freisling, Heinz
Weiderpass, Elisabete
Hughes, David J.
Eriksen, Anne Kirstine
Tjønneland, Anne
Severi, Gianluca
Rothwell, Joseph
Boutron-Ruault, Marie Christine
Katzke, Verena
Kaaks, Rudolf
Schulze, Matthias B.
Birukov, Anna
Krogh, Vittorio
Panico, Salvatore
Tumino, Rosario
Ricceri, Fulvio
Bueno de Mesquita, H. Bas
Vermeulen, Roel C.H.
Gram, Inger T.
Skeie, Guri
Sandanger, Torkjel M.
Quirós, J. Ramón
Crous Bou, Marta
Sánchez, María José
Amiano, Pilar
Chirlaque, María Dolores
Barricarte Gurrea, Aurelio
Manjer, Jonas
Johansson, Ingegerd
Pérez Cornago, Aurora
Jenab, Mazda
Fedirko, Veronika
Keywords: Nutrició
Càncer colorectal
Colorectal cancer
Issue Date: 10-Dec-2021
Publisher: MDPI AG
Abstract: Advanced glycation end-products (AGEs) may promote oxidative stress and inflammation and have been linked to multiple chronic diseases, including cancer. However, the association of AGEs with mortality after colorectal cancer (CRC) diagnosis has not been previously investigated. Multivariable Cox proportional hazards models were used to calculate hazard ratios and corresponding 95% confidence intervals for associations between dietary intake of AGEs with CRC-specific and all-cause mortality among 5801 participant cases diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition study between 1993 and 2013. Dietary intakes of AGEs were estimated using country-specific dietary questionnaires, linked to an AGE database, that accounted for food preparation and processing. During a median of 58 months of follow-up, 2421 cases died (1841 from CRC). Individually or combined, dietary intakes of AGEs were not associated with all-cause and CRC-specific mortality among cases. However, there was a suggestion for a positive association between AGEs and all-cause or CRC-specific mortality among CRC cases without type II diabetes (all-cause, P-interaction = 0.05) and CRC cases with the longest follow-up between recruitment and cancer diagnosis (CRC-specific, P-interaction = 0.003; all-cause, P-interaction = 0.01). Our study suggests that pre-diagnostic dietary intakes of AGEs were not associated with CRC-specific or all-cause mortality among CRC patients. Further investigations using biomarkers of AGEs and stratifying by sex, diabetes status, and timing of exposure to AGEs are warranted.
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It is part of: Nutrients, 2021, vol 13, num 12, p. 4435
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ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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