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Title: | Cancer impact prognosis on mortality in patients with acute heart failure: analysis of the epicter study |
Author: | Mendez Bailon, Manuel Lorenzo Villalba, Noel Romero-Correa, Miriam Guisado-Espartero, Esther González-Soler, Juan Rugeles-Niño, Jessica Sebastián-Leza, Angel Ceresuela-Eito, Luis Romaní-Costa, Verónica Quesada Simón, Maria Angustias Soler-Rangel, Llanos Herrero-Domingo, Almudena Díez-García, Luis Alcalá Pedrajas, José Nicolás Villalonga-Comas, María Andrès, Emmanuel Gudiñ-Aguirre, Diego Formiga Pérez, Francesc Aramburu-Bodas, Óscar Arias Jimenez, Jose Luis Salamanca-Bautista, Prado |
Keywords: | Insuficiència cardíaca Mortalitat Càncer Heart failure Mortality Cancer |
Issue Date: | 24-Jan-2022 |
Publisher: | MDPI |
Abstract: | Introduction: Heart failure (HF) and cancer are currently the leading causes of death worldwide, with an increasing incidence with age. Little is known about the treatment received and the prognosis of patients with acute HF and a prior cancer diagnosis. Objective: to determine the clinical characteristics, palliative treatment received, and prognostic impact of patients with acute HF and a history of solid tumor. Methods: The EPICTER study ('Epidemiological survey of advanced heart failure') is a cross-sectional, multicenter project that consecutively collected patients admitted for acute HF in 74 Spanish hospitals. Patients were classified into two groups according to whether they met criteria for acute HF with and without solid cancer, and the groups were subsequently compared. A multivariable logistic regression analysis was conducted, using the forward stepwise method. A Kaplan-Meier survival analysis was performed to evaluate the impact of solid tumor on prognosis in patients with acute HF. Results: A total of 3127 patients were included, of which 394 patients (13%) had a prior diagnosis of some type of solid cancer. Patients with a history of cancer presented a greater frequency of weight loss at admission: 18% vs. 12% (p = 0.030). In the cancer group, functional impairment was noted more frequently: 43% vs. 35%, p = 0.039). Patients with a history of solid cancer more frequently presented with acute HF with preserved ejection fraction (65% vs. 58%, p = 0.048) than reduced or mildly reduced. In-hospital and 6-month follow-up mortality was 31% (110/357) in patients with solid cancer vs. 26% (637/2466), p = 0.046. Conclusion: Our investigation demonstrates that in-hospital mortality and mortality during 6-month follow-up in patients with acute HF were higher in those subjects with a history of concomitant solid tumor cancer diagnosis. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/jcm11030571 |
It is part of: | Journal of Clinical Medicine, 2022, vol. 11, num. 3 |
URI: | http://hdl.handle.net/2445/182740 |
Related resource: | https://doi.org/10.3390/jcm11030571 |
ISSN: | 2077-0383 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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