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DC Field | Value | Language |
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dc.contributor.author | Pérez Recio, Sandra | - |
dc.contributor.author | Pallarès, Natàlia | - |
dc.contributor.author | Grijota Camino, Maria D. | - |
dc.contributor.author | Sánchez Montalvá, Adrián | - |
dc.contributor.author | Barcia, Laura | - |
dc.contributor.author | Campos Gutiérrez, Silvia | - |
dc.contributor.author | Pomar, Virginia | - |
dc.contributor.author | Rabuñal Rey, Ramón | - |
dc.contributor.author | Balcells, Maria Elvira | - |
dc.contributor.author | Gazel, Deniz | - |
dc.contributor.author | Montiel, Natalia | - |
dc.contributor.author | Vicente, Diego | - |
dc.contributor.author | Goić-Barišić, Ivana | - |
dc.contributor.author | Schön, Thomas | - |
dc.contributor.author | Paues, Jakob | - |
dc.contributor.author | Mareković, Ivana | - |
dc.contributor.author | Cacho Calvo, Juana | - |
dc.contributor.author | Barac, Aleksandra | - |
dc.contributor.author | Goletti, Delia | - |
dc.contributor.author | García Gasalla, Mercedes | - |
dc.contributor.author | Barcala, José Maria | - |
dc.contributor.author | Tórtola, María Teresa | - |
dc.contributor.author | Anibarro, Luis | - |
dc.contributor.author | Suárez Toste, Isabel | - |
dc.contributor.author | Moga, Esther | - |
dc.contributor.author | Gude Gonzalez, María J. | - |
dc.contributor.author | Naves, Rodrigo | - |
dc.contributor.author | Karslıgil, Tekin | - |
dc.contributor.author | Martin Peñaranda, Tania | - |
dc.contributor.author | Stevanovic, Goran | - |
dc.contributor.author | Trigo, Matilde | - |
dc.contributor.author | Rubio, Verónica | - |
dc.contributor.author | Karaoğlan,, Ilkay | - |
dc.contributor.author | Bayram, Nazan | - |
dc.contributor.author | Alcaide, Fernando | - |
dc.contributor.author | Tebé, Cristian | - |
dc.contributor.author | Santín Cerezales, Miguel | - |
dc.date.accessioned | 2022-02-02T09:12:17Z | - |
dc.date.available | 2022-02-02T09:12:17Z | - |
dc.date.issued | 2021-11-10 | - |
dc.identifier.issn | 2165-0497 | - |
dc.identifier.uri | http://hdl.handle.net/2445/182859 | - |
dc.description.abstract | We investigated whether the difference of antigen tube 2 (TB2) minus antigen tube 1 (TB1) (TB22TB1) of the QuantiFERON-TB gold plus test, which has been postulated as a surrogate for the CD81 T-cell response, could be useful in identifying recent tuberculosis (TB) exposure. We looked at the interferon gamma (IFN-g) responses and differences in TB2 and TB1 tubes for 686 adults with QFT-plus positive test results. These results were compared among groups with high (368 TB contacts), low (229 patients with immune-mediated inflammatory diseases [IMID]), and indeterminate (89 asylum seekers or people from abroad [ASPFA]) risks of recent TB exposure. A TB22TB1 value .0.6 IU ml21 was deemed to indicate a true difference between tubes. In the whole cohort, 13.6%, 10.9%, and 11.2% of cases had a TB2.TB1 result in the contact, IMID, and ASPFA groups, respectively (P = 0.591). The adjusted odds ratios (aORs) for an association between a TB22TB1 result of .0.6 IU ml21 and risk of recent exposure versus contacts were 0.71 (95% confidence interval [CI], 0.31 to 1.61) for the IMID group and 0.86 (95% CI, 0.49 to 1.52) for the ASPFA group. In TB contact subgroups, 11.4%, 5.4%, and 17.7% with close, frequent, and sporadic contact had a TB2.TB1 result (P = 0.362). The aORs versus the close subgroup were 1.29 (95% CI, 0.63 to 2.62) for the frequent subgroup and 1.55 (95% CI, 0.67 to 3.60) for the sporadic subgroup. A TB22TB1 difference of .0.6 IU ml21 was not associated with increased risk of recent TB exposure, which puts into question the clinical potential as a proxy marker for recently acquired TB infection. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Society for Microbiology Press, Washington DC, USA, | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1128/Spectrum.00972-21 | - |
dc.relation.ispartof | Microbiology Spectrum, 2021, vol. 9 , num. 3 | - |
dc.relation.uri | https://doi.org/10.1128/Spectrum.00972-21 | - |
dc.rights | cc-by (c) Pérez Recio, Sandra et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Proves funcionals (Medicina) | - |
dc.subject.classification | Tuberculosi | - |
dc.subject.other | Function tests (Medicine) | - |
dc.subject.other | Tuberculosis | - |
dc.title | Identification of recent tuberculosis exposure using QuantiFERON-TB Gold Plus, a multicenter study. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 716161 | - |
dc.date.updated | 2022-02-02T09:12:17Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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716161.pdf | 1.13 MB | Adobe PDF | View/Open |
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