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http://hdl.handle.net/2445/182964
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DC Field | Value | Language |
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dc.contributor.author | Loftfield, Erikka | - |
dc.contributor.author | Stepien, Magdalena | - |
dc.contributor.author | Viallon, Vivian | - |
dc.contributor.author | Trijsburg, Laura | - |
dc.contributor.author | Rothwell, Joseph A. | - |
dc.contributor.author | Robinot, Nivonirina | - |
dc.contributor.author | Biessy, Carine | - |
dc.contributor.author | Bergdahl, Ingvar A. | - |
dc.contributor.author | Bodén, Stina | - |
dc.contributor.author | Schulze, Matthias B. | - |
dc.contributor.author | Bergman, Manuela | - |
dc.contributor.author | Weiderpass, Elisabete | - |
dc.contributor.author | Schmidt, Julie A. | - |
dc.contributor.author | Zamora-Ros, Raul | - |
dc.contributor.author | Nøst, Therese Haugdahl | - |
dc.contributor.author | Sandanger, Torkjel M. | - |
dc.contributor.author | Sonestedt, Emily | - |
dc.contributor.author | Ohlsson, Bodil | - |
dc.contributor.author | Katzke, Verena | - |
dc.contributor.author | Kaaks, Rudolf | - |
dc.contributor.author | Ricceri, Fulvio | - |
dc.contributor.author | Tjønneland, Anne | - |
dc.contributor.author | Dahm, Christina C. | - |
dc.contributor.author | Sánchez, Maria José | - |
dc.contributor.author | Trichopoulou, Antonia | - |
dc.contributor.author | Tumino, Rosario | - |
dc.contributor.author | Chirlaque, María Dolores | - |
dc.contributor.author | Masala, Giovanna | - |
dc.contributor.author | Ardanaz, Eva | - |
dc.contributor.author | Vermeulen, Roel | - |
dc.contributor.author | Brennan, Paul | - |
dc.contributor.author | Albanes, Demetrius | - |
dc.contributor.author | Weinstein, Stephanie J. | - |
dc.contributor.author | Scalbert, Augustin | - |
dc.contributor.author | Freedman, Neal D. | - |
dc.contributor.author | Gunter, Marc J. | - |
dc.contributor.author | Jenab, Mazda | - |
dc.contributor.author | Sinha, Rashmi | - |
dc.contributor.author | Keski-Rahkonen, Pekka | - |
dc.contributor.author | Ferrari, Pietro | - |
dc.date.accessioned | 2022-02-04T17:32:28Z | - |
dc.date.available | 2022-05-19T05:10:24Z | - |
dc.date.issued | 2021-05-19 | - |
dc.identifier.issn | 1460-2105 | - |
dc.identifier.uri | http://hdl.handle.net/2445/182964 | - |
dc.description.abstract | Background: Alcohol is an established risk factor for several cancers, but modest alcohol-cancer associations may be missed because of measurement error in self-reported assessments. Biomarkers of habitual alcohol intake may provide novel insight into the relationship between alcohol and cancer risk. Methods: Untargeted metabolomics was used to identify metabolites correlated with self-reported habitual alcohol intake in a discovery dataset from the European Prospective Investigation into Cancer and Nutrition (EPIC; n = 454). Statistically significant correlations were tested in independent datasets of controls from case-control studies nested within EPIC (n = 280) and the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC; n = 438) study. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations of alcohol-associated metabolites and self-reported alcohol intake with risk of pancreatic cancer, hepatocellular carcinoma (HCC), liver cancer, and liver disease mortality in the contributing studies. Results: Two metabolites displayed a dose-response association with self-reported alcohol intake: 2-hydroxy-3-methylbutyric acid and an unidentified compound. A 1-SD (log2) increase in levels of 2-hydroxy-3-methylbutyric acid was associated with risk of HCC (OR = 2.54, 95% CI = 1.51 to 4.27) and pancreatic cancer (OR = 1.43, 95% CI = 1.03 to 1.99) in EPIC and liver cancer (OR = 2.00, 95% CI = 1.44 to 2.77) and liver disease mortality (OR = 2.16, 95% CI = 1.63 to 2.86) in ATBC. Conversely, a 1-SD (log2) increase in questionnaire-derived alcohol intake was not associated with HCC or pancreatic cancer in EPIC or liver cancer in ATBC but was associated with liver disease mortality (OR = 2.19, 95% CI = 1.60 to 2.98) in ATBC. Conclusions: 2-hydroxy-3-methylbutyric acid is a candidate biomarker of habitual alcohol intake that may advance the study of alcohol and cancer risk in population-based studies. | ca |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.publisher | Oxford University Press (OUP) | ca |
dc.relation.isformatof | Postprint del document publicat a: https://doi.org/10.1093/jnci/djab078 | - |
dc.relation.ispartof | JNCI: Journal of the National Cancer Institute, 2021, vol 113, num 11, p. 1542-1550 | - |
dc.relation.uri | https://doi.org/10.1093/jnci/djab078 | - |
dc.rights | (c) Loftfield, Erikka et al., 2021 | - |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Alcohol | - |
dc.subject.classification | Càncer | - |
dc.subject.other | Alcohol | - |
dc.subject.other | Cancer | - |
dc.title | Novel Biomarkers of Habitual Alcohol Intake and Associations With Risk of Pancreatic and Liver Cancers and Liver Disease Mortality | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2022-02-03T10:21:33Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 34010397 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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2021.03.12.20224451v1.full.pdf | 486.45 kB | Adobe PDF | View/Open |
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