Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/182976
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Toda, Haruka | - |
dc.contributor.author | Díaz Varela, Míriam | - |
dc.contributor.author | Seguí Barber, Joan | - |
dc.contributor.author | Roobsoong, Wanlapa | - |
dc.contributor.author | Baro, Barbara | - |
dc.contributor.author | Garcia Silva, Susana | - |
dc.contributor.author | Galiano, Alicia | - |
dc.contributor.author | Gualdrón López, Melisa | - |
dc.contributor.author | Almeida, Anne Cristine Gomes | - |
dc.contributor.author | Brito, Marcelo A. M. | - |
dc.contributor.author | Cardoso de Melo, Gisely | - |
dc.contributor.author | Aparici Herraiz, Iris | - |
dc.contributor.author | Castro Cavadía, Carlos | - |
dc.contributor.author | Monteiro, Wuelton Marcelo | - |
dc.contributor.author | Borràs, Eva | - |
dc.contributor.author | Sabidó Aguadé, Eduard | - |
dc.contributor.author | Almeida, Igor Correia de | - |
dc.contributor.author | Chojnacki, Jakub | - |
dc.contributor.author | Martínez Picado, Francisco Javier | - |
dc.contributor.author | Calvo, Maria | - |
dc.contributor.author | Armengol, Maria del Pilar | - |
dc.contributor.author | Carmona Fonseca, Jaime | - |
dc.contributor.author | Yasnot, María Fernanda | - |
dc.contributor.author | Lauzurica, Ricardo | - |
dc.contributor.author | Marcilla, Antonio | - |
dc.contributor.author | Peinado, Hector | - |
dc.contributor.author | Galinski, Mary R. | - |
dc.contributor.author | Lacerda, Marcus V. G. | - |
dc.contributor.author | Sattabongkot, Jetsumon | - |
dc.contributor.author | Fernández Becerra, Carmen | - |
dc.contributor.author | Portillo, Hernando A. del | - |
dc.date.accessioned | 2022-02-07T08:39:03Z | - |
dc.date.available | 2022-02-07T08:39:03Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2445/182976 | - |
dc.description.abstract | Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) are therefore major components of circulating plasma holding insights into pathological processes. Here, we demonstrate that plasma-derived EVs from Plasmodium vivax patients (PvEVs) are preferentially uptaken by human spleen fibroblasts (hSFs) as compared to the uptake of EVs from healthy individuals. Moreover, this uptake induces specific upregulation of ICAM-1 associated with the translocation of NF-kB to the nucleus. After this uptake, P. vivax-infected reticulocytes obtained from patients show specific adhesion properties to hSFs, reversed by inhibiting NF-kB translocation to the nucleus. Together, these data provide physiological EV-based insights into the mechanisms of human malaria pathology and support the existence of P. vivax-adherent parasite subpopulations in the microvasculature of the human spleen. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/ 10.1038/s41467-020-16337-y | - |
dc.relation.ispartof | Nature Communications, 2020, vol 11 | - |
dc.relation.uri | http://dx.doi.org/ 10.1038/s41467-020-16337-y | - |
dc.rights | cc by (c) Toda, Haruka et al, 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Malària | - |
dc.subject.classification | Relacions hoste-paràsit | - |
dc.subject.other | Malaria | - |
dc.subject.other | Host-parasite relationships | - |
dc.title | Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-02-04T19:00:42Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/793830/EU//HIV VCC Interference | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32487994 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Toda_H_Nat_Commun_2020.pdf | 2.54 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License