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Title: New Formulations Loading Caspofungin for Topical Therapy of Vulvovaginal Candidiasis
Author: Pérez-González, Noelia
Bozal de Febrer, Núria
Calpena Campmany, Ana Cristina
Nardi Ricart, Anna
Rodríguez Lagunas, María José
Morales-Molina, José A.
Soriano-Ruiz, José L.
Fernández Campos, Francisco
Clares Naveros, Beatriz
Keywords: Candidiasi
Malalties de l'aparell genital femení
Medicaments antifúngics
Female reproductive system diseases
Antifungal agents
Issue Date: 12-Dec-2021
Abstract: Vulvovaginal candidiasis (VVC) poses a significant problem worldwide affecting women from all strata of society. It is manifested as changes in vaginal discharge, irritation, itching and stinging sensation. Although most patients respond to topical treatment, there is still a need for increase the therapeutic arsenal due to resistances to anti-infective agents. The present study was designed to develop and characterize three hydrogels of chitosan (CTS), Poloxamer 407 (P407) and a combination of both containing 2% caspofungin (CSP) for the vaginal treatment of VVC. CTS was used by its mucoadhesive properties and P407 was used to exploit potential advantages related to increasing drug concentration in order to provide a local effect. The formulations were physically, mechanically and morphologically characterized. Drug release profile and ex vivo vaginal permeation studies were performed. Antifungal efficacy against different strains of Candida spp. was also evaluated. In addition, tolerance of formulations was studied by histological analysis. Results confirmed that CSP hydrogels could be proposed as promising candidates for the treatment of VVC
Note: Reproducció del document publicat a:
It is part of: Gels, 2021, num. 7, p. 259
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ISSN: 2310-2861
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Bioquímica i Fisiologia)

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