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http://hdl.handle.net/2445/183066
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DC Field | Value | Language |
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dc.contributor.author | Rakislova, Natalia | - |
dc.contributor.author | Alemany i Vilches, Laia | - |
dc.contributor.author | Clavero, Omar | - |
dc.contributor.author | Pino, Marta del | - |
dc.contributor.author | Saco, Adela | - |
dc.contributor.author | Marimon, Lorena | - |
dc.contributor.author | Quirós, Beatriz | - |
dc.contributor.author | Lloveras Rubio, Betlem | - |
dc.contributor.author | Ribera Cortada, Inmaculada | - |
dc.contributor.author | Alejo, Maria | - |
dc.contributor.author | Pawlita, Michael | - |
dc.contributor.author | Quint, Wim | - |
dc.contributor.author | Sanjosé Llongueras, Silvia de | - |
dc.contributor.author | Ordi i Majà, Jaume | - |
dc.contributor.author | VVAP Study Group | - |
dc.date.accessioned | 2022-02-14T07:40:48Z | - |
dc.date.available | 2022-02-14T07:40:48Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 0147-5185 | - |
dc.identifier.uri | http://hdl.handle.net/2445/183066 | - |
dc.description.abstract | Two etiopathogenic types of vulvar squamous cell carcinoma (VSCC) have been described: human papillomavirus (HPV)-associated and HPV-independent. Precursor lesions, frequently identified in the adjacent skin, are also distinct in the 2 types of VSCC: high-grade squamous intraepithelial lesions (HSILs) in HPV-associated VSCC and differentiated vulvar intraepithelial neoplasia (dVIN) or vulvar acanthosis with altered differentiation in HPV-independent VSCC. Although HPV-independent precursors mimicking HSIL have been described in the vulva, their frequency and morphologic spectrum have not been completely characterized. We explored, in a large series of HPV-independent VSSC, the frequency and the histologic features of precursors mimicking HSIL. We included 779 DNA HPV-negative/p16-negative VSCC with at least 1\xE2\x80\x89cm of adjacent skin. We evaluated the histologic and immunohistochemical (p16 and p53) characteristics of the intraepithelial lesions, focusing on precursors mimicking HPV-associated vulvar HSIL. A total of 254 tumors (33%) had adjacent premalignant lesions. Of them, 186 (73%) had dVIN, 22 (9%) had vulvar acanthosis with altered differentiation, and 46 (18%) had lesions that mimicked HSIL. The mean age of the patients with these HSIL-like lesions was 72\xC2\xB115 years. Twenty-six of these HSIL-like lesions had basaloid morphology, 13 warty, and 7 mixed basaloid/warty features. All the HSIL-like precursors were DNA HPV-negative/p16-negative; 74% of them showed p53 abnormal staining and 35% of them had areas of conventional dVIN. In conclusion, about one fifth of the HPV-independent precursors mimic HSIL, showing either basaloid or warty features. Older age and the presence of areas of typical HPV-independent intraepithelial lesions, together with p16 negativity, should raise suspicion of an HPV-independent etiology. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wolters Kluwer Health | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/ 10.1097/PAS.0000000000001540 | - |
dc.relation.ispartof | American Journal of Surgical Pathology, 2020, vol 44, num 11, p. 1506-1514 | - |
dc.relation.uri | http://dx.doi.org/ 10.1097/PAS.0000000000001540 | - |
dc.rights | (c) Wolters Kluwer Health, 2020 | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Papil·lomavirus | - |
dc.subject.classification | Diagnòstic | - |
dc.subject.other | Papillomaviruses | - |
dc.subject.other | Diagnosis | - |
dc.title | HPV-independent Precursors Mimicking High-grade Squamous intraepithelial Lesions (HSIL) of the Vulva | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2022-02-11T19:00:40Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32657782 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
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Postprint_Ordi_J_Am_J_Surg_Pathol_2020.pdf | 641.38 kB | Adobe PDF | View/Open |
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