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https://hdl.handle.net/2445/183080Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Masoumi, Farimah | - |
| dc.contributor.author | Saraiva, Sofia M. | - |
| dc.contributor.author | Bouzo, Belén L. | - |
| dc.contributor.author | López López, Rafael | - |
| dc.contributor.author | Esteller, Manel | - |
| dc.contributor.author | Diaz-Lagares, Angel | - |
| dc.contributor.author | de la Fuente, María | - |
| dc.date.accessioned | 2022-02-10T18:31:33Z | - |
| dc.date.available | 2022-02-10T18:31:33Z | - |
| dc.date.issued | 2021-09-01 | - |
| dc.identifier.issn | 1999-4923 | - |
| dc.identifier.uri | https://hdl.handle.net/2445/183080 | - |
| dc.description.abstract | Long non-coding RNAs (lncRNAs) are an emerging group of RNAs with a crucial role in cancer pathogenesis. In gastrointestinal cancers, TP53 target 1 (TP53TG1) is an epigenetically regulated lncRNA that represents a promising therapeutic target due to its tumor suppressor properties regulating the p53-mediated DNA damage and the intracellular localization of the oncogenic YBX1 protein. However, to translate this finding into the clinic as a gene therapy, it is important to develop effective carriers able to deliver exogenous lncRNAs to the targeted cancer cells. Here, we propose the use of biocompatible sphingomyelin nanosystems comprising DOTAP (DSNs) to carry and deliver a plasmid vector encoding for TP53TG1 (pc(TP53TG1)-DSNs) to a colorectal cancer cell line (HCT-116). DSNs presented a high association capacity and convenient physicochemical properties. In addition, pc(TP53TG1)-DSNs showed anti-tumor activities in vitro, specifically a decrease in the proliferation rate, a diminished colony-forming capacity, and hampered migration and invasiveness of the treated cancer cells. Consequently, the proposed strategy displays a high potential as a therapeutic approach for colorectal cancer. Keywords: long non-coding RNAs; epigenomics; colorectal cancer; nanocarriers; emulsions | - |
| dc.format.extent | 16 p. | - |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | eng | - |
| dc.publisher | MDPI | - |
| dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/pharmaceutics13091507 | - |
| dc.relation.ispartof | Pharmaceutics, 2021, vol. 13, num. 9, p. 1507-1522 | - |
| dc.relation.uri | https://doi.org/10.3390/pharmaceutics13091507 | - |
| dc.rights | cc-by (c) Masoumi, Farimah et al., 2021 | - |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
| dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
| dc.subject.classification | Càncer colorectal | - |
| dc.subject.classification | Epigenètica | - |
| dc.subject.classification | RNA | - |
| dc.subject.classification | Nanomedicina | - |
| dc.subject.other | Colorectal cancer | - |
| dc.subject.other | Epigenetics | - |
| dc.subject.other | RNA | - |
| dc.subject.other | Nanomedicine | - |
| dc.title | Modulation of colorectal tumor behavior via lncRNA TP53TG1-lipidic nanosystem | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.identifier.idgrec | 715840 | - |
| dc.date.updated | 2022-02-10T18:31:34Z | - |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
| dc.identifier.pmid | 34575588 | - |
| Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 715840.pdf | 1.42 MB | Adobe PDF | View/Open |
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