Please use this identifier to cite or link to this item:
Title: Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials
Author: Gutiérrez, Laia
Folch, Alexandre
Rojas, Melina
Cantero, Jose L.
Atienza, Mercedes
Folch, Jaume
Camins Espuny, Antoni
Ruiz, Agustín
Papandreou, Christopher
Bulló, Mònica
Keywords: Malaltia d'Alzheimer
Alzheimer's disease
Issue Date: 1-Nov-2021
Publisher: MDPI
Abstract: New dietary approaches for the prevention of cognitive impairment are being investigated. However, evidence from dietary interventions is mainly from food and nutrient supplement interventions, with inconsistent results and high heterogeneity between trials. We conducted a comprehensive systematic search of randomized controlled trials (RCTs) published in MEDLINE-PubMed, from January 2018 to July 2021, investigating the impact of dietary counseling, as well as food-based and dietary supplement interventions on cognitive function in adults with or without cognitive impairment. Based on the search strategy, 197 eligible publications were used for data abstraction. Finally, 61 articles were included in the analysis. There was reasonable evidence that dietary patterns, as well as food and dietary supplements improved cognitive domains or measures of brain integrity. The Mediterranean diet showed promising results, whereas the role of the DASH diet was not clear. Healthy food consumption improved cognitive function, although the quality of these studies was relatively low. The role of dietary supplements was mixed, with strong evidence of the benefits of polyphenols and combinations of nutrients, but with low evidence for PUFAs, vitamin D, specific protein, amino acids, and other types of supplements. Further well-designed RCTs are needed to guide the development of dietary approaches for the prevention of cognitive impairment.
Note: Reproducció del document publicat a:
It is part of: Nutrients, 2021, vol. 13, num. 11, p. 1-40
Related resource:
ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

Files in This Item:
File Description SizeFormat 
716508.pdf3.82 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons