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DC Field | Value | Language |
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dc.contributor.author | Carrera, Mª José | - |
dc.contributor.author | Moliner, Pedro | - |
dc.contributor.author | Llauradó, Gemma | - |
dc.contributor.author | Enjuanes, Cristina | - |
dc.contributor.author | Conangla, Laura | - |
dc.contributor.author | Chillarón, Juan José | - |
dc.contributor.author | Ballesta, Silvia | - |
dc.contributor.author | Climent, Elisenda | - |
dc.contributor.author | Comín Colet, Josep | - |
dc.contributor.author | Flores le Roux, Juana Antonia | - |
dc.date.accessioned | 2022-02-11T16:43:03Z | - |
dc.date.available | 2022-02-11T16:43:03Z | - |
dc.date.issued | 2021-12-21 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | http://hdl.handle.net/2445/183105 | - |
dc.description.abstract | Acute hyperglycemia has been associated with worse prognosis in patients hospitalized for heart failure (HF). Nevertheless, studies evaluating the impact of glycemic control on long-term prognosis have shown conflicting results. Our aim was to assess the relationship between acute-to-chronic (A/C) glycemic ratio and 4-year mortality in a cohort of subjects hospitalized for acute HF. A total of 1062 subjects were consecutively included. We measured glycaemia at admission and estimated average chronic glucose levels and the A/C glycemic ratio were calculated. Subjects were stratified into groups according to the A/C glycemic ratio tertiles. The primary endpoint was 4-year mortality. Subjects with diabetes had higher risk for mortality compared to those without (HR 1.35 [95% CI: 1.10-1.65]; p = 0.004). A U-shape curve association was found between glucose at admission and mortality, with a HR of 1.60 [95% CI: 1.22-2.11]; p = 0.001, and a HR of 1.29 [95% CI: 0.97-1.70]; p = 0.078 for the first and the third tertile, respectively, in subjects with diabetes. Additionally, the A/C glycemic ratio was negatively associated with mortality (HR 0.76 [95% CI: 0.58-0.99]; p = 0.046 and HR 0.68 [95% CI: 0.52-0.89]; p = 0.005 for the second and third tertile, respectively). In multivariable analysis, the A/C glycemic ratio remained an independent predictor. In conclusion, in subjects hospitalized for acute HF, the A/C glycemic ratio is significantly associated with mortality, improving the ability to predict mortality compared with glucose levels at admission or average chronic glucose concentrations, especially in subjects with diabetes. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI AG | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/jcm11010006 | - |
dc.relation.ispartof | Journal of Clinical Medicine, 2021, vol 11, num 1 | - |
dc.relation.uri | https://doi.org/10.3390/jcm11010006 | - |
dc.rights | cc by (c) Carrera, Mª José et al, 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Insuficiència cardíaca | - |
dc.subject.classification | Diabetis | - |
dc.subject.other | Heart failure | - |
dc.subject.other | Diabetes | - |
dc.title | Prognostic Value of the Acute-to-Chronic Glycemic Ratio at Admission in Heart Failure: A Prospective Study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | http://hdl.handle.net/2445/183105 | - |
dc.date.updated | 2022-02-11T10:32:02Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 35011747 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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jcm-11-00006-v3.pdf | 9.39 MB | Adobe PDF | View/Open |
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