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Title: Focusing on Comorbidity A Novel Meta-Analytic Approach and Protocol to Disentangle the Specific Neuroanatomy of Co-occurring Mental Disorders
Author: Fortea, Lydia
Albajes Eizagirre, Anton
Yao, Yuan Wei
Soler, Edu
Verdolini, Norma
Hauson, Alexander O.
Fortea, Adriana
Madero, Santiago
Solanes, Aleix
Wollman, Scott C.
Serra Blasco, María
Wise, Toby
Lukito, Steve
Picó Pérez, María
Carlisi, Christina
Zhang, Jin Tao
Pan, PingLei
Farré Colomés, Álvar
Arnone, Danilo
Kempton, Matthew J.
Soriano Mas, Carles
Rubia, Katya
Norman, Luke
Fusar-Poli, Paolo
Mataix Cols, David
Valentí Ribas, Marc
Via, Esther
Cardoner, N. (Narcís)
Solmi, Marco
Shin, Jae I.
Vieta i Pascual, Eduard, 1963-
Radua, Joaquim
Keywords: Malalties mentals
Imatges per ressonància magnètica
Mental illness
Magnetic resonance imaging
Issue Date: 18-Jan-2022
Publisher: Frontiers Media
Abstract: Background: In mental health, comorbidities are the norm rather than the exception. However, current meta-analytic methods for summarizing the neural correlates of mental disorders do not consider comorbidities, reducing them to a source of noise and bias rather than benefitting from their valuable information. Objectives: We describe and validate a novel neuroimaging meta-analytic approach that focuses on comorbidities. In addition, we present the protocol for a meta-analysis of all major mental disorders and their comorbidities. Methods: The novel approach consists of a modification of Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) in which the linear models have no intercept. As in previous SDM meta-analyses, the dependent variable is the brain anatomical difference between patients and controls in a voxel. However, there is no primary disorder, and the independent variables are the percentages of patients with each disorder and each pair of potentially comorbid disorders. We use simulations to validate and provide an example of this novel approach, which correctly disentangled the abnormalities associated with each disorder and comorbidity. We then describe a protocol for conducting the new meta-analysis of all major mental disorders and their comorbidities. Specifically, we will include all voxel-based morphometry (VBM) studies of mental disorders for which a meta-analysis has already been published, including at least 10 studies. We will use the novel approach to analyze all included studies in two separate single linear models, one for children/adolescents and one for adults. Discussion: The novel approach is a valid method to focus on comorbidities. The meta-analysis will yield a comprehensive atlas of the neuroanatomy of all major mental disorders and their comorbidities, which we hope might help develop potential diagnostic and therapeutic tools.
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It is part of: Frontiers In Psychiatry, 2022, vol. 12, num. 807839
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ISSN: 1664-0640
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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