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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/183210
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dc.contributor.authorPrischich, Davia-
dc.contributor.authorGiralt Lledó, Ernest-
dc.contributor.authorHernando, Jordi-
dc.contributor.authorGuasch i Casany, Eduard-
dc.contributor.authorMeana, J. Javier-
dc.contributor.authorVilla, Pedro de la-
dc.contributor.authorGorostiza Langa, Pablo Ignacio-
dc.contributor.authorGomila Juaneda, Alexandre-
dc.contributor.authorMilla Navarro, Santiago-
dc.contributor.authorSangüesa Puigventós, Gemma-
dc.contributor.authorDiez Alarcia, Rebeca-
dc.contributor.authorPreda, Beatrice-
dc.contributor.authorMatera, Carlo-
dc.contributor.authorBatlle, Montserrat-
dc.date.accessioned2022-02-16T13:58:24Z-
dc.date.available2022-02-16T13:58:24Z-
dc.date.issued2021-02-15-
dc.identifier.issn1521-3773-
dc.identifier.urihttps://hdl.handle.net/2445/183210-
dc.description.abstract© 2020 Wiley-VCH GmbH Adrenoceptors are ubiquitous and mediate important autonomic functions as well as modulating arousal, cognition, and pain on a central level. Understanding these physiological processes and their underlying neural circuits requires manipulating adrenergic neurotransmission with high spatio-temporal precision. Here we present a first generation of photochromic ligands (adrenoswitches) obtained via azologization of a class of cyclic amidines related to the known ligand clonidine. Their pharmacology, photochromism, bioavailability, and lack of toxicity allow for broad biological applications, as demonstrated by controlling locomotion in zebrafish and pupillary responses in mice.-
dc.format.extent7 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherJohn Wiley and Sons-
dc.relation.isformatofPostprint del document publicat a: https://doi.org/10.1002/anie.202010553-
dc.relation.ispartofAngewandte Chemie, 2021, vol 60, num 7, p. 3625-3631-
dc.relation.urihttps://doi.org/10.1002/anie.202010553-
dc.rights(c) Wiley-VCH, 2021-
dc.sourceArticles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))-
dc.subject.classificationNeurotransmissors-
dc.subject.classificationReceptors adrenèrgics-
dc.subject.otherNeurotransmitters-
dc.subject.otherAdrenaline receptors-
dc.titleAdrenergic Modulation With Photochromic Ligands-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.date.updated2022-02-16T06:39:24Z-
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/945539/EU//HBP SGA3-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.idimarina6467569-
dc.identifier.pmid33103317-
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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