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Title: Leishmaniosis caused by Leishmania infantum in ferrets: Update review
Author: Villanueva-Saz, Sergio
Giner, Jacobo
Marteles, Diana
Verde, María Teresa
Yzuel, Andrés
Riera Lizandra, Ma. Cristina
Fisa Saladrigas, Roser
Alcover Amengual, Maria Magdalena
Fernández, Antonio
Keywords: Leishmaniosi
Malalties infeccioses en els animals
Parasitologia veterinària
Communicable diseases in animals
Veterinary parasitology
Issue Date: 23-Dec-2021
Abstract: Leishmaniosis in domestic ferrets (Mustela putorius furo) is a disease caused by Leishmania infantum, a parasite transmitted through the bite of an infected female phlebotomine sand fly. Among vertebrates, the dog is the primary domestic reservoir of the parasite; however, other domestic animals can be implicated such as cats. The first description of a clinical case of leishmaniosis in domestic ferrets was reported recently. As a result, new knowledge has been published including empirically based treatment protocols, confirmatory techniques to detect the presence of the parasite infection and seasonal variation in the antibodies against Leishmania in apparently healthy domestic ferrets. The most common clinical signs observed are enlargement of peripheral lymph nodes and skin lesions such as papular and/or ulcerative dermatitis. Additionally, the most frequent laboratory alterations seen are hyperproteinaemia with hyperglobulinaemia and biochemical analytes alterations depending on the affected tissue. Two different therapeutic protocols have been described to treat domestic ferrets with leishmaniosis: meglumine antimoniate plus allopurinol protocol or miltefosine plus allopurinol protocol. These treatment protocols seemed to be able to control the Leishmania infection, although the presence of xanthinuria could be detected. The susceptibility of domestic ferrets to Leishmania infantum, the clinical picture, treatment of infected animals and prevention are poorly understood, due to the scarcity of recent description in the literature. Different proposed diagnostic algorithms have been included for domestic ferrets with suspected leishmaniosis, clinically healthy domestic ferrets and animals as blood donors. In this sense, the present review provides updated data on scientific knowledge of leishmaniosis in ferrets.
It is part of: Veterinary and Animal Science, 2021
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ISSN: 2451-943X
Appears in Collections:Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)

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