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http://hdl.handle.net/2445/183294
Title: | Alkaloid escholidine and its interaction with DNA structures |
Author: | Jarosova, Petra Hannig, Pavel Kolkova, Katerina Mazzini, Stefania Taborska, Eva Gargallo Gómez, Raimundo Borgonovo, Gigliola Artali, Roberto Taborsky, Petr |
Keywords: | ADN Càncer Alcaloides DNA Cancer Alkaloids |
Issue Date: | Nov-2021 |
Publisher: | MDPI |
Abstract: | Berberine, the most known quaternary protoberberine alkaloid (QPA), has been reported to inhibit the SIK3 protein connected with breast cancer. Berberine also appears to reduce the bcl-2 and XIAP expression-proteins responsible for the inhibition of apoptosis. As some problems in the therapy with berberine arose, we studied the DNA binding properties of escholidine, another QPA alkaloid. CD, fluorescence, and NMR examined models of i-motif and G-quadruplex sequences present in the n-myc gene and the c-kit gene. We provide evidence that escholidine does not induce stabilization of the i-motif sequences, while the interaction with G-quadruplex structures appears to be more significant. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/biology10121225 |
It is part of: | Biology-Basel, 2021, vol. 10, num. 12, p. 1225 |
URI: | http://hdl.handle.net/2445/183294 |
Related resource: | https://doi.org/10.3390/biology10121225 |
ISSN: | 2079-7737 |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
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