Please use this identifier to cite or link to this item:
Title: Prediction of Chemotoxicity, Unplanned Hospitalizations and Early Death in Older Patients with Colorectal Cancer Treated with Chemotherapy
Author: Feliu, Jaime
Espinosa, Enrique
Basterretxea, Laura
Paredero, Irene
Llabrés, Elisenda
Jiménez Munárriz, Beatriz
Antonio, Maite
Losada, Beatriz
Pinto, Alvaro
Custodio, Ana Belén
Muñoz, María del Mar
Gómez-mediavilla, Jenifer
Torregrosa, María Dolores
Soler, Gema
Cruz, Patricia
Higuera, Oliver
Molina Garrido, María José
Keywords: Càncer colorectal
Quimioteràpia del càncer
Colorectal cancer
Cancer chemotherapy
Issue Date: 28-Dec-2021
Publisher: MDPI AG
Abstract: Simple Summary Chemotoxicity, unplanned hospitalizations (Uhs) and early death (ED) are common among older patients with cancer who receive chemotherapy. Our objective was to determine factors predicting these complications. A predictive score for these three complications based on geriatric, tumor and laboratory variables was developed in a series of 215 older patients with colorectal carcinoma receiving chemotherapy. The use of this score may reliably identify patients at risk to have excessive toxicity with chemotherapy, UH or ED, thus helping to plan treatment, implement adaptive measures, and intensify follow-up. Purpose: To identify risk factors for toxicity, unplanned hospitalization (UH) and early death (ED) in older patients with colorectal carcinoma (CRC) initiating chemotherapy. Methods: 215 patients over 70 years were prospectively included. Geriatric assessment was performed before treatment, and tumor and treatment variables were collected. The association between these factors and grade 3-5 toxicity, UH and ED (<6 months) was examined by using multivariable logistic regression. Score points were assigned to each risk factor. Results: During the first 6 months of treatment, 33% of patients developed grade 3-5 toxicity, 31% had UH and 23% died. Risk factors were, for toxicity, instrumental activities of daily living, creatinine clearance, weight loss and MAX2 index; for UH, Charlson Comorbidity Score, creatinine clearance, weight loss, serum albumin, and metastatic disease; and for ED, basic activities in daily living, weight loss, metastatic disease, and hemoglobin levels. Predictive scores were built with these variables. The areas under receiver operation characteristic (ROC) curves for toxicity, UH and ED were 0.70 (95% CI: 0.64-0.766), 0.726 (95% IC: 0.661-0.799) and 0.74 (95% IC: 0.678-0.809), respectively. Conclusion: Simple scores based on geriatric, tumor and laboratory characteristics predict severe toxicity, UH and ED, and may help in treatment planning.
Note: Reproducció del document publicat a:
It is part of: Cancers, 2021, vol 14, num 1
Related resource:
ISSN: 2072-6694
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
cancers-14-00127.pdf621.45 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons