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http://hdl.handle.net/2445/183423
Title: | Design of the β3-Adrenergic Agonist Treatment in Chronic Pulmonary Hypertension Secondary to Heart Failure Trial |
Author: | García Lunar, Isabel Blanco Vich, Isabel Fernández Friera, Leticia Prat González, Susanna Jordà, Paloma Sánchez, Javier Pereda, Daniel Pujadas, Sandra Rivas Lasarte, Mercedes Solé González, Eduard Vázquez, Jorge Blázquez Bermejo, Zorba García Picart, Juan Caravaca Pérez. Pedro Escalera, Noemí Garcia Pavia, Pablo Delgado Jiménez, Juan Segovia Cubero, Javier Fuster, Valentín Roig i Minguell, Eulàlia Barberà i Mir, Joan Albert Ibáñez Cabeza, Borja García Álvarez, Ana |
Keywords: | Simpatomimètics Hipertensió pulmonar Sympathomimetic agents Pulmonary hypertension |
Issue Date: | 11-Mar-2020 |
Abstract: | Combined pre-and post-capillary hypertension (CpcPH) is a relatively common complication of heart failure (HF) associated with a poor prognosis. Currently, there is no specific therapy approved for this entity. Recently, treatment with beta-3 adrenergic receptor (β3AR) agonists was able to improve pulmonary hemodynamics and right ventricular (RV) performance in a translational, large animal model of chronic PH. The authors present the design of a phase II randomized clinical trial that tests the benefits of mirabegron (a clinically available β3AR agonist) in patients with CpcPH due to HF. The effect of β3AR treatment will be evaluated on pulmonary hemodynamics, as well as clinical, biochemical, and advanced cardiac imaging parameters. (Beta3 Agonist Treatment in Chronic Pulmonary Hypertension Secondary to Heart Failure [SPHERE-HF]; NCT02775539). |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.jacbts.2020.01.009 |
It is part of: | Jacc-Basic To Translational Science, 2020, vol. 5, num. 4, p. 317-327 |
URI: | http://hdl.handle.net/2445/183423 |
Related resource: | https://doi.org/10.1016/j.jacbts.2020.01.009 |
ISSN: | 2452-302X |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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