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http://hdl.handle.net/2445/183447
Title: | Aging Impairs Reverse Remodeling and Recovery of Ventricular Function after Isoproterenol-Induced Cardiomyopathy |
Author: | Yáñez Bisbe, Laia Garcia Elias, Anna Tajes, Marta Almendros López, Isaac Rodríguez Sinovas, Antonio Inserte, Javier Ruiz Meana, Marisol Farré Ventura, Ramon Farré, Núria Benito, Begoña |
Keywords: | Insuficiència cardíaca Envelliment Malalties del cor Heart failure Aging Heart diseases |
Issue Date: | 1-Dec-2021 |
Publisher: | MDPI |
Abstract: | Abstract: Information about heart failure with reduced ejection fraction (HFrEF) in women and the potential effects of aging in the female heart is scarce. We investigated the vulnerability to develop HFrEF in female elderly mice compared to young animals, as well as potential differences in reverse remodeling. First, HF was induced by isoproterenol infusion (30 mg/kg/day, 28 days) in young (10-week-old) and elderly (22-month-old) female mice. In a second set of animals, mice underwent isoproterenol infusion followed by no treatment during 28 additional days. Cardiac remodeling was assessed by echocardiography, histology and gene expression of collagen-I and collagen-III. Following isoproterenol infusion, elderly mice developed similar HFrEF features compared to young animals, except for greater cell hypertrophy and tissue fibrosis. After beta-adrenergic withdrawal, young female mice experienced complete reversal of the HFrEF phenotype. Conversely, reversed remodeling was impaired in elderly animals, with no significant recovery of LV ejection fraction, cardiomyocyte hypertrophy and collagen deposition. In conclusion, chronic isoproterenol infusion is a valid HF model for elderly and young female mice and induces a similar HF phenotype in both. Elderly animals, unlike young, show impaired reverse remodeling, with persistent tissue fibrosis and cardiac dysfunction even after beta-adrenergic withdrawal. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijms23010174 |
It is part of: | International Journal of Molecular Sciences, 2021, vol. 23, num. 1, p. 174 |
URI: | http://hdl.handle.net/2445/183447 |
Related resource: | https://doi.org/10.3390/ijms23010174 |
ISSN: | 1661-6596 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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