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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/183467
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dc.contributor.authorCalon, Alexandre-
dc.contributor.authorEspinet, Elisa-
dc.contributor.authorPalomo Ponce, Sergio-
dc.contributor.authorTauriello, Daniele V. F.-
dc.contributor.authorIglesias, Mar-
dc.contributor.authorCespedes, María Virtudes-
dc.contributor.authorSevillano, Marta-
dc.contributor.authorNadal, Cristina-
dc.contributor.authorJung, Peter-
dc.contributor.authorZhang, Xiang H. F.-
dc.contributor.authorByrom, Daniel-
dc.contributor.authorRiera i Escalé, Antoni-
dc.contributor.authorRossell, David-
dc.contributor.authorMangues, Ramon-
dc.contributor.authorMassagué i Solé, Joan, 1953--
dc.contributor.authorSancho, Elena-
dc.contributor.authorBatlle, Eduard-
dc.date.accessioned2022-02-24T19:00:57Z-
dc.date.available2022-02-24T19:00:57Z-
dc.date.issued2014-03-05-
dc.identifier.issn2331-8325-
dc.identifier.urihttp://hdl.handle.net/2445/183467-
dc.description.abstractWe sought to understand the mechanisms behind the potent effect of stromal TGF-beta program on the capacity of colorectal cancer (CRC) cells to initiate metastasis. We discovered that mice subcutaneous tumors and metastases generated in the context of a TGF-beta activated microenvironment displayed prominent accumulation of p-STAT3 in CRC cells compared with those derived from control cells. STAT3 signaling depended on GP130 as shown by strong reduction of epithelial p STAT3 levels upon GP130 shRNA-mediated knockdown in CRC cells.-
dc.format.extent4 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.21769/BioProtoc.1120-
dc.relation.ispartofBio-protocol, 2014, vol. 4, num. 9, p. e1120-
dc.relation.urihttps://doi.org/10.21769/BioProtoc.1120-
dc.rights(c) Bio-protocol LLC, 2014-
dc.sourceArticles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))-
dc.subject.classificationCàncer colorectal-
dc.subject.classificationMetàstasi-
dc.subject.classificationExpressió gènica-
dc.subject.otherColorectal cancer-
dc.subject.otherMetastasis-
dc.subject.otherGene expression-
dc.titleImmunostaining Protocol: P-Stat3 (Xenograft and Mice)-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.date.updated2022-02-24T12:05:43Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.idimarina6544612-
Appears in Collections:Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

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