Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/183467
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DC Field | Value | Language |
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dc.contributor.author | Calon, Alexandre | - |
dc.contributor.author | Espinet, Elisa | - |
dc.contributor.author | Palomo Ponce, Sergio | - |
dc.contributor.author | Tauriello, Daniele V. F. | - |
dc.contributor.author | Iglesias, Mar | - |
dc.contributor.author | Cespedes, María Virtudes | - |
dc.contributor.author | Sevillano, Marta | - |
dc.contributor.author | Nadal, Cristina | - |
dc.contributor.author | Jung, Peter | - |
dc.contributor.author | Zhang, Xiang H. F. | - |
dc.contributor.author | Byrom, Daniel | - |
dc.contributor.author | Riera i Escalé, Antoni | - |
dc.contributor.author | Rossell, David | - |
dc.contributor.author | Mangues, Ramon | - |
dc.contributor.author | Massagué i Solé, Joan, 1953- | - |
dc.contributor.author | Sancho, Elena | - |
dc.contributor.author | Batlle, Eduard | - |
dc.date.accessioned | 2022-02-24T19:00:57Z | - |
dc.date.available | 2022-02-24T19:00:57Z | - |
dc.date.issued | 2014-03-05 | - |
dc.identifier.issn | 2331-8325 | - |
dc.identifier.uri | http://hdl.handle.net/2445/183467 | - |
dc.description.abstract | We sought to understand the mechanisms behind the potent effect of stromal TGF-beta program on the capacity of colorectal cancer (CRC) cells to initiate metastasis. We discovered that mice subcutaneous tumors and metastases generated in the context of a TGF-beta activated microenvironment displayed prominent accumulation of p-STAT3 in CRC cells compared with those derived from control cells. STAT3 signaling depended on GP130 as shown by strong reduction of epithelial p STAT3 levels upon GP130 shRNA-mediated knockdown in CRC cells. | - |
dc.format.extent | 4 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.21769/BioProtoc.1120 | - |
dc.relation.ispartof | Bio-protocol, 2014, vol. 4, num. 9, p. e1120 | - |
dc.relation.uri | https://doi.org/10.21769/BioProtoc.1120 | - |
dc.rights | (c) Bio-protocol LLC, 2014 | - |
dc.source | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Metàstasi | - |
dc.subject.classification | Expressió gènica | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Metastasis | - |
dc.subject.other | Gene expression | - |
dc.title | Immunostaining Protocol: P-Stat3 (Xenograft and Mice) | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-02-24T12:05:43Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 6544612 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
Files in This Item:
File | Description | Size | Format | |
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Bio-protocol1120.pdf | 440.08 kB | Adobe PDF | View/Open |
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