Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/183522
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DC Field | Value | Language |
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dc.contributor.author | Calon, Alexandre | - |
dc.contributor.author | Espinet, Elisa | - |
dc.contributor.author | Palomo Ponce, Sergio | - |
dc.contributor.author | Tauriello, Daniele V. F. | - |
dc.contributor.author | Iglesias, Mar | - |
dc.contributor.author | Céspedes, María | - |
dc.contributor.author | Sevillano, Marta | - |
dc.contributor.author | Nadal, Cristina | - |
dc.contributor.author | Jung, Peter | - |
dc.contributor.author | Zhang, Xiang | - |
dc.contributor.author | Byrom, Daniel | - |
dc.contributor.author | Riera i Escalé, Antoni | - |
dc.contributor.author | Rossell, David | - |
dc.contributor.author | Mangues, Ramon | - |
dc.contributor.author | Massagué i Solé, Joan, 1953- | - |
dc.contributor.author | Sancho, Elena | - |
dc.contributor.author | Batlle, Eduard | - |
dc.date.accessioned | 2022-02-24T19:00:17Z | - |
dc.date.available | 2022-02-24T19:00:17Z | - |
dc.date.issued | 2014-05-05 | - |
dc.identifier.issn | 2331-8325 | - |
dc.identifier.uri | http://hdl.handle.net/2445/183522 | - |
dc.description.abstract | Metastasis depends on a gene program expressed by the tumor microenvironment upon TGF-beta stimulation. CRC (Colorectal cancer) cell lines did not induce robust stromal TGF- beta responses when injected into nude mice as shown by lack of p- SMAD2 accumulation in tumor-associated stromal cells. To enforce high TGF-beta signaling in xenografts, we engineered CRC cell lines to secrete active TGF-beta. Subcutaneous tumors obtained from HT29-M6TGF-β, KM12L4aTGF-β cells and SW48TGF-β cells contained abundant p-SMAD2+ stromal cells. | - |
dc.format.extent | 4 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.21769/bioprotoc.1119 | - |
dc.relation.ispartof | Bio-protocol, 2014, vol. 4, num. 9, p. e1119 | - |
dc.relation.uri | https://doi.org/10.21769/bioprotoc.1119 | - |
dc.rights | (c) Bio-protocol LLC, 2014 | - |
dc.source | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Metàstasi | - |
dc.subject.classification | Expressió gènica | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Metastasis | - |
dc.subject.other | Gene expression | - |
dc.title | Immunostaining Protocol: P-Smad2 (Xenograft and Mice) | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-02-24T12:05:08Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 6544613 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
Files in This Item:
File | Description | Size | Format | |
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Bio-protocol1119.pdf | 522.96 kB | Adobe PDF | View/Open |
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