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http://hdl.handle.net/2445/183707
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DC Field | Value | Language |
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dc.contributor.author | Ramírez, Sara | - |
dc.contributor.author | Haddad Tovolli, Roberta | - |
dc.contributor.author | Radosevic, Marija | - |
dc.contributor.author | Toledo Soler, Miriam | - |
dc.contributor.author | Pané, Adriana | - |
dc.contributor.author | Alcolea, Daniel | - |
dc.contributor.author | Ribas, Vicent | - |
dc.contributor.author | Pozo, Macarena | - |
dc.contributor.author | Obri, Arnaud | - |
dc.contributor.author | Milà Guasch, Maria | - |
dc.contributor.author | Eyre, Elena | - |
dc.contributor.author | Gómez Valadés, Alicia G. | - |
dc.contributor.author | Chivite, Iñigo | - |
dc.contributor.author | Van Eeckhout, Tomas | - |
dc.contributor.author | Zalachoras, Ioannis | - |
dc.contributor.author | Altirriba Gutiérrez, Jordi | - |
dc.contributor.author | Bauder, Corinna | - |
dc.contributor.author | Imbernón, Mónica | - |
dc.contributor.author | Garrabou Tornos, Glòria | - |
dc.contributor.author | García Ruiz, Carmen | - |
dc.contributor.author | Nogueiras, Rubén | - |
dc.contributor.author | Soto del Cerro, David | - |
dc.contributor.author | Gasull Casanova, Xavier | - |
dc.contributor.author | Sandi, Carmen | - |
dc.contributor.author | Brüning, Jens C. | - |
dc.contributor.author | Fortea Ormaechea, Juan | - |
dc.contributor.author | Jiménez, Amanda | - |
dc.contributor.author | Fernández-Checa Torres, José Carlos | - |
dc.contributor.author | Claret i Carles, Marc | - |
dc.date.accessioned | 2022-03-02T18:28:32Z | - |
dc.date.available | 2022-03-02T18:28:32Z | - |
dc.date.issued | 2022-02-01 | - |
dc.identifier.issn | 1550-4131 | - |
dc.identifier.uri | http://hdl.handle.net/2445/183707 | - |
dc.description.abstract | Obesity and type-2 diabetes are associated with cognitive dysfunction. Since the hypothalamus is implicated in energy balance control and memory disorders, we hypothesized that specific neurons in this brain region are at the interface of metabolism and cognition. Acute obesogenic diet administration in mice impaired recognition memory due to defective production of the neurosteroid-precursor pregnenolone in the hypothalamus. Genetic interference with pregnenolone synthesis by Star deletion in hypothalamic POMC, but not AgRP neurons, deteriorated recognition memory independently of metabolic disturbances. Our data suggested that pregnenolone's effects on cognitive function were mediated via an autocrine mechanism on POMC neurons, influencing hippocampal long-term potentiation. The relevance of central pregnenolone on cognition was also confirmed in metabolically-unhealthy obese patients. Our data reveals an unsuspected role for POMC neuron-derived neurosteroids in cognition. These results provide the basis for a framework to investigate new facets of POMC neuron biology with implications for cognitive disorders. | - |
dc.format.extent | 26 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Cell Press | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.cmet.2021.12.023 | - |
dc.relation.ispartof | Cell Metabolism, 2021, vol. 34, num. 2, p. 269-284 | - |
dc.relation.uri | https://doi.org/10.1016/j.cmet.2021.12.023 | - |
dc.rights | cc-by-nc-nd (c) Elsevier, 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Trastorns del metabolisme | - |
dc.subject.classification | Hipotàlem | - |
dc.subject.classification | Trastorns de la memòria | - |
dc.subject.other | Disorders of metabolism | - |
dc.subject.other | Hypothalamus | - |
dc.subject.other | Memory disorders | - |
dc.title | Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 717138 | - |
dc.date.updated | 2022-03-02T18:28:32Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 9297129 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut de Neurociències (UBNeuro)) Articles publicats en revistes (Biomedicina) |
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717138.pdf | 5.42 MB | Adobe PDF | View/Open |
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