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Title: Regioselective alkylation reaction of purines under microwave irradiation
Author: Vinuesa, Arturo
Viñas, Miquel
Jahani, Daniel
Ginard, Jaume
Mur, Nuria
Pujol Dilmé, M. Dolors
Keywords: Purines
Compostos heterocíclics
Síntesi orgànica
Heterocyclic compounds
Organic synthesis
Issue Date: 18-Nov-2021
Publisher: Wiley
Abstract: The alkylation of purines which is generally carried out after anion formation by treatment with a base and alkyl halide is complicated and in the best cases, mixtures of N-alkylated compounds are obtained. Purine derivatives can be acquired from alkylation at N-7 and N-9. In this work, the reaction conditions have been optimized to obtain the alkylation products of N-9 regioselectively. Different bases have been tried and tetrabutylammonium hydroxide has led to the best results. The reaction depends on the type of base and solvent used and improves considerably when the aid of microwave irradiation is used, which also considerably reduces the reaction time by reducing the formation of secondary products.
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It is part of: Journal of Heterocyclic Chemistry, 2021, vol. open access, p. open access
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ISSN: 0022-152X
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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