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Títol: Regioselective alkylation reaction of purines under microwave irradiation
Autor: Vinuesa, Arturo
Viñas, Miquel
Jahani, Daniel
Ginard, Jaume
Mur, Nuria
Pujol Dilmé, M. Dolors
Matèria: Purines
Compostos heterocíclics
Síntesi orgànica
Purines
Heterocyclic compounds
Organic synthesis
Data de publicació: 18-nov-2021
Publicat per: Wiley
Resum: The alkylation of purines which is generally carried out after anion formation by treatment with a base and alkyl halide is complicated and in the best cases, mixtures of N-alkylated compounds are obtained. Purine derivatives can be acquired from alkylation at N-7 and N-9. In this work, the reaction conditions have been optimized to obtain the alkylation products of N-9 regioselectively. Different bases have been tried and tetrabutylammonium hydroxide has led to the best results. The reaction depends on the type of base and solvent used and improves considerably when the aid of microwave irradiation is used, which also considerably reduces the reaction time by reducing the formation of secondary products.
Nota: Reproducció del document publicat a: https://doi.org/10.1002/jhet.4407
És part de: Journal of Heterocyclic Chemistry, 2021, vol. open access, p. open access
URI: https://hdl.handle.net/2445/183716
Recurs relacionat: https://doi.org/10.1002/jhet.4407
ISSN: 0022-152X
Apareix en les col·leccions:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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