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Title: A Mouse Model Suggests That Heart Failure and Its Common Comorbidity Sleep Fragmentation Have No Synergistic Impacts on the Gut Microbiome
Author: Khannous-Lleiffe, Olfat
Willis, Jesse R.
Saus, Ester
Cabrera Aguilera, Ignacio
Almendros López, Isaac
Farré Ventura, Ramon
Gozal, David
Farré, Núria
Gabaldón, Toni
Keywords: Models animals en la investigació
Insuficiència cardíaca
Microbiota intestinal
Animal models in research
Heart failure
Gastrointestinal microbiome
Issue Date: 19-Mar-2021
Publisher: MDPI
Abstract: Heart failure (HF) is a common condition associated with a high rate of hospitalizations and adverse outcomes. HF is characterized by impairments of either the cardiac ventricular filling, ejection of blood capacity or both. Sleep fragmentation (SF) involves a series of short sleep interruptions that lead to fatigue and contribute to cognitive impairments and dementia. Both conditions are known to be associated with increased inflammation and dysbiosis of the gut microbiota. In the present study, mice were distributed into four groups, and subjected for four weeks to either HF, SF, both HF and SF, or left unperturbed as controls. We used 16S metabarcoding to assess fecal microbiome composition before and after the experiments. Evidence for distinct alterations in several bacterial groups and an overall decrease in alpha diversity emerged in HF and SF treatment groups. Combined HF and SF conditions, however, showed no synergism, and observed changes were not always additive, suggesting preliminarily that some of the individual effects of either HF or SF cancel each other out when applied concomitantly.
Note: Reproducció del document publicat a:
It is part of: Microorganisms, 2021, vol. 9, num. 3, p. 641-657
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ISSN: 2076-2607
Appears in Collections:Articles publicats en revistes (Biomedicina)
Publicacions de projectes de recerca finançats per la UE

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