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Title: In the Era of mRNA Vaccines, Is There Any Hope for HIV Functional Cure?
Author: Esteban, Ignasi
Pastor Quiñones, Carmen
Usero, Lorena
Plana Prades, Montserrat
Garcia, Felipe
Leal, Lorna
Keywords: Vacunes antivíriques
VIH (Virus)
Viral vaccines
HIV (Viruses)
Issue Date: 1-Mar-2021
Publisher: MDPI
Abstract: Over 36 million people worldwide are infected with HIV. Antiretroviral therapy (ART) has proven to be highly effective to prevent HIV-1 transmission, clinical progression and death. Despite this success, the number of HIV-1 infected individuals continues increasing and ART should be taken for life. Therefore, there are two main priorities: the development of preventive vaccines to protect from HIV acquisition and achieve an efficient control of HIV infection in the absence of ART (functional cure). In this sense, in the last few years, there has been a broad interest in new and innovative approaches such as mRNA-based vaccines. RNA-based immunogens represent a promising alternative to conventional vaccines because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration. Some mRNA-based vaccines platforms against infectious diseases have demonstrated encouraging results in animal models and humans. However, their application is still limited because the instability and inefficient in vivo delivery of mRNA. Immunogens, design, immunogenicity, chemical modifications on the molecule or the vaccine delivery methods are all crucial interventions for improvement. In this review we, will present the current knowledge and challenges in this research field. mRNA vaccines hold great promises as part of a combined strategy, for achieving HIV functional cure.
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It is part of: Viruses, 2021, vol 13, num 3
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ISSN: 1999-4915
Appears in Collections:Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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