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http://hdl.handle.net/2445/183808Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Terra, Ximena | - |
| dc.contributor.author | Ceperuelo Mallafré, Victoria | - |
| dc.contributor.author | Merma, Carla | - |
| dc.contributor.author | Benaiges, Ester | - |
| dc.contributor.author | Bosch, Ramon | - |
| dc.contributor.author | Castillo, Paola | - |
| dc.contributor.author | Flores, Joan Carles | - |
| dc.contributor.author | Leon, Xavier | - |
| dc.contributor.author | Valduvieco, Izaskun | - |
| dc.contributor.author | Baste, Neus | - |
| dc.contributor.author | Camara, Marina | - |
| dc.contributor.author | Lejeune, Marylene | - |
| dc.contributor.author | Guma, Josep | - |
| dc.contributor.author | Vendrell, Joan | - |
| dc.contributor.author | Vilaseca, Isabel | - |
| dc.contributor.author | Fernandez Veledo, Sonia | - |
| dc.contributor.author | Avilés Jurado, Francesc Xavier | - |
| dc.date.accessioned | 2022-03-04T19:12:16Z | - |
| dc.date.available | 2022-03-04T19:12:16Z | - |
| dc.date.issued | 2021-04-01 | - |
| dc.identifier.issn | 2072-6694 | - |
| dc.identifier.uri | http://hdl.handle.net/2445/183808 | - |
| dc.description.abstract | Simple Summary: Emerging evidence points to succinate as an important oncometabolite in cancer development; however, the contribution of the succinate-SUCNR1 axis to cancer progression remains unclear. Head and neck squamous cell carcinoma (HNSCC) is associated with disease and treatmentrelated morbidity so there is an urgent need for innovation in treatment and diagnosis practices. Our aim was to evaluate the potential of the succinate-related pathway as a diagnostic and prognostic biomarker in HNSCC. The circulating succinate levels are increased in HNSCC, being a potential noninvasive biomarker for HNSCC diagnosis. Moreover, the succinate receptor (SUCNR1) and genes related to succinate metabolism, which are predominantly expressed in the tumoral mucosa as compared with healthy tissue, are positively associated with plasma succinate. Remarkably, we found that SUCNR1 and SDHA expression levels predict prognosis. | - |
| dc.format.extent | 16 p. | - |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | eng | - |
| dc.publisher | MDPI | - |
| dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/cancers13071653 | - |
| dc.relation.ispartof | Cancers, 2021, vol 13, num 7, p. 1-16 | - |
| dc.relation.uri | https://doi.org/10.3390/cancers13071653 | - |
| dc.rights | cc-by (c) Terra, Ximena et al., 2021 | - |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
| dc.source | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) | - |
| dc.subject.classification | Càncer de cap | - |
| dc.subject.classification | Càncer de coll | - |
| dc.subject.other | Head cancer | - |
| dc.subject.other | Neck cancer | - |
| dc.title | Succinate Pathway in Head and Neck Squamous Cell Carcinoma: Potential as a Diagnostic and Prognostic Marker | - |
| dc.type | info:eu-repo/semantics/article | - |
| dc.type | info:eu-repo/semantics/publishedVersion | - |
| dc.identifier.idgrec | 713992 | - |
| dc.date.updated | 2022-03-04T19:11:56Z | - |
| dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
| dc.identifier.pmid | 33916314 | - |
| Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 713992.pdf | 1.74 MB | Adobe PDF | View/Open |
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