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Title: | The PPARβ/δ-AMPK Connection in the Treatment of Insulin Resistance |
Author: | Aguilar-Recarte, David Palomer Tarridas, Francesc Xavier Wahli, Walter Vázquez Carrera, Manuel |
Keywords: | Trastorns del metabolisme dels lípids Àcids grassos Receptors nuclears (Bioquímica) Glucosa Lipid metabolism disorders Fatty acids Nuclear receptors (Biochemistry) Glucose |
Issue Date: | 9-Aug-2021 |
Publisher: | MDPI |
Abstract: | The current treatment options for type 2 diabetes mellitus do not adequately control the disease in many patients. Consequently, there is a need for new drugs to prevent and treat type 2 diabetes mellitus. Among the new potential pharmacological strategies, activators of peroxisome proliferator-activated receptor (PPAR)β/δ show promise. Remarkably, most of the antidiabetic effects of PPARβ/δ agonists involve AMP-activated protein kinase (AMPK) activation. This review summarizes the recent mechanistic insights into the antidiabetic effects of the PPARβ/δ-AMPK pathway, including the upregulation of glucose uptake, muscle remodeling, enhanced fatty acid oxidation, and autophagy, as well as the inhibition of endoplasmic reticulum stress and inflammation. A better understanding of the mechanisms underlying the effects resulting from the PPARβ/δ-AMPK pathway may provide the basis for the development of new therapies in the prevention and treatment of insulin resistance and type 2 diabetes mellitus. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijms22168555 |
It is part of: | International Journal of Molecular Sciences, 2021, vol. 22, num. 16, p. 8555 |
URI: | http://hdl.handle.net/2445/183848 |
Related resource: | https://doi.org/10.3390/ijms22168555 |
ISSN: | 1661-6596 |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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