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Title: | The Positive Rhinovirus/Enterovirus Detection and SARS-CoV-2 Persistence beyond the Acute Infection Phase: An Intra-Household Surveillance Study. |
Author: | Brotons, Pedro Jordan Garcia, Iolanda Bassat Orellana, Quique Henares, Desiree Fernandez de Sevilla, M Ajanovic, Sara Redin, A. Fumadó, Victoria Baro, Bàrbara Claverol, Joana Varo, Rosauro Cuadras, Daniel Hecht, Jochen Barrabeig i Fabregat, Irene García García, Juan José Launes Montaña, Cristian Muñoz-Almagro, Carmen |
Keywords: | SARS-CoV-2 Enterovirus Llar SARS-CoV-2 Enteroviruses Home |
Issue Date: | 12-Aug-2021 |
Publisher: | MDPI |
Abstract: | We aimed to assess the duration of nasopharyngeal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA persistence in adults self-confined at home after acute infection; and to identify the associations of SARS-CoV-2 persistence with respiratory virus co-detection and infection transmission. A cross-sectional intra-household study was conducted in metropolitan Barcelona (Spain) during the time period of April to June 2020. Every adult who was the first family member reported as SARS-CoV-2-positive by reverse transcription polymerase chain reaction (RT-PCR) as well as their household child contacts had nasopharyngeal swabs tested by a targeted SARS-CoV-2 RT-PCR and a multiplex viral respiratory panel after a 15 day minimum time lag. Four-hundred and four households (404 adults and 708 children) were enrolled. SARS-CoV-2 RNA was detected in 137 (33.9%) adults and 84 (11.9%) children. Rhinovirus/Enterovirus (RV/EV) was commonly found (83.3%) in co-infection with SARS-CoV-2 in adults. The mean duration of SARS-CoV-2 RNA presence in adults' nasopharynx was 52 days (range 26-83 days). The persistence of SARS-CoV-2 was significantly associated with RV/EV co-infection (adjusted odds ratio (aOR) 9.31; 95% CI 2.57-33.80) and SARS-CoV-2 detection in child contacts (aOR 2.08; 95% CI 1.24-3.51). Prolonged nasopharyngeal SARS-CoV-2 RNA persistence beyond the acute infection phase was frequent in adults quarantined at home during the first epidemic wave; which was associated with RV/EV co-infection and could enhance intra-household infection transmission. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/v13081598 |
It is part of: | Viruses, 2021, vol. 13, num. 8, p. 1598 |
URI: | http://hdl.handle.net/2445/183875 |
Related resource: | https://doi.org/10.3390/v13081598 |
ISSN: | 1999-4915 |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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