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Title: The thalamus and its subnuclei—a gateway to obsessive-compulsive disorder
Author: Weeland, Cees J.
Kasprzak, Selina
Joode, Niels T. de
Abe, Yoshinari
Alonso, Pino
Ameis, Stephanie H.
Anticevic, Alan
Arnold, Paul D.
Balachander, Srinivas
Banaj, Nerisa
Bargalló Alabart, Núria​
Wang, Zhen
Watanabe, Anri
Wolters, Lidewij H.
Xu, Xiufeng
Yun, Je-Yeon
Zhao, Qing
White, Tonya
Thompson, Paul M.
Stein, Dan J.
Heuvel, Odile A. van den
Vriend, Chris
ENIGMA-OCD Working Group
Batistuzzo, Marcelo C.
Benedetti, Francesco
Beucke, Jan C.
Bollettini, Irene
Brecke, Vilde
Brem, Silvia
Cappi, Carolina
Cheng, Yuqi
Cho, Kang Ik K.
Costa, Daniel L. C.
Dallaspezia, Sara
Denys, Damiaan
Eng, Goi Khia
Ferreira, Sónia
Feusner, Jamie D.
Fontaine, Martine
Fouche, Jean Paul
Grazioplene, Rachael G.
Gruner, Patricia
He, Mengxin
Hirano, Yoshiyuki
Hoexter, Marcelo Q.
Huyser, Chaim
Hu, Hao
Jaspers-Fayer, Fern
Kathmann, Norbert
Kaufmann, Christian
Kim, Minah
Koch, Kathrin
Bin Kwak, Yoo
Kwon, Jun Soo
Lazaro, Luisa
Li, Chiang-Shan R.
Lochner, Christine
Marsh, Rachel
Martínez Zalacaín, Ignacio
Mataix Cols, David
Menchón, Jose M.
Minnuzi, Luciano
Moreira, Pedro Silva
Morgado, Pedro
Nakagawa, Akiko
Nakamae, Takashi
Narayanaswamy, Janardhanan C.
Nurmi, Erika L.
Ortiz, Ana E.
Pariente, Jose C.
Piacentini, John
Picó Pérez, Maria
Piras, Fabrizio
Piras, Federica
Pittenger, Christopher
Reddy, Y. C. Janardhan
Rodriguez Manrique, Daniela
Sakai, Yuki
Shimizu, Eiji
Shivakumar, Venkataram
Simpson, Helen Blair
Soreni, Noam
Soriano Mas, Carles
Sousa, Nuno
Spalletta, Gianfranco
Stern, Emily R.
Stevens, Michael C.
Stewart, S. Evelyn
Szeszko, Philip R.
Takahashi, Jumpei
Tanamatis, Tais
Tang, Jinsong
Thorsen, Anders Lillevik
Tolin, David
Werf, Ysbrand D. van der
Van Marle, Hein
Wingen, Guido A. van
Vecchio, Daniela
Venkatasubramanian, G.
Walitza, Susanne
Wang, Jicai
Keywords: Tàlem (Anatomia)
Conducta compulsiva
Compulsive behavior
Issue Date: 21-Feb-2022
Publisher: Springer Science and Business Media LLC
Abstract: Larger thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population. Particular thalamic subregions may drive these differences. The ENIGMA-OCD working group conducted mega- and meta-analyses to study thalamic subregional volume in OCD across the lifespan. Structural T-1-weighted brain magnetic resonance imaging (MRI) scans from 2649 OCD patients and 2774 healthy controls across 29 sites (50 datasets) were processed using the FreeSurfer built-in ThalamicNuclei pipeline to extract five thalamic subregions. Volume measures were harmonized for site effects using ComBat before running separate multiple linear regression models for children, adolescents, and adults to estimate volumetric group differences. All analyses were pre-registered ( and adjusted for age, sex and intracranial volume. Unmedicated pediatric OCD patients (<12 years) had larger lateral (d = 0.46), pulvinar (d = 0.33), ventral (d = 0.35) and whole thalamus (d = 0.40) volumes at unadjusted p-values <0.05. Adolescent patients showed no volumetric differences. Adult OCD patients compared with controls had smaller volumes across all subregions (anterior, lateral, pulvinar, medial, and ventral) and smaller whole thalamic volume (d = -0.15 to -0.07) after multiple comparisons correction, mostly driven by medicated patients and associated with symptom severity. The anterior thalamus was also significantly smaller in patients after adjusting for thalamus size. Our results suggest that OCD-related thalamic volume differences are global and not driven by particular subregions and that the direction of effects are driven by both age and medication status.
Note: Reproducció del document publicat a:
It is part of: Translational Psychiatry, 2022, vol 12, num 1
Related resource:
ISSN: 2158-3188
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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