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http://hdl.handle.net/2445/183907
Title: | Molecular Mechanisms of Kidney Injury and Repair |
Author: | Rayego Mateos, Sandra Marquez Expósito, Laura Rodrigues Diez, Raquel Sanz, Ana B. Guiteras, Roser Doladé, Nuria Rubio Soto, Irene Manonelles, Anna Codina, Sergi Ortiz, Alberto Cruzado, Josep M. Ruiz Ortega, Marta Sola, Anna |
Keywords: | Malalties del fetge Medicina regenerativa Liver diseases Regenerative medicine |
Issue Date: | 28-Jan-2022 |
Publisher: | MDPI AG |
Abstract: | Chronic kidney disease (CKD) will become the fifth global cause of death by 2040, thus emphasizing the need to better understand the molecular mechanisms of damage and regeneration in the kidney. CKD predisposes to acute kidney injury (AKI) which, in turn, promotes CKD progression. This implies that CKD or the AKI-to-CKD transition are associated with dysfunctional kidney repair mechanisms. Current therapeutic options slow CKD progression but fail to treat or accelerate recovery from AKI and are unable to promote kidney regeneration. Unraveling the cellular and molecular mechanisms involved in kidney injury and repair, including the failure of this process, may provide novel biomarkers and therapeutic tools. We now review the contribution of different molecular and cellular events to the AKI-to-CKD transition, focusing on the role of macrophages in kidney injury, the different forms of regulated cell death and necroinflammation, cellular senescence and the senescence-associated secretory phenotype (SAPS), polyploidization, and podocyte injury and activation of parietal epithelial cells. Next, we discuss key contributors to repair of kidney injury and opportunities for their therapeutic manipulation, with a focus on resident renal progenitor cells, stem cells and their reparative secretome, certain macrophage subphenotypes within the M2 phenotype and senescent cell clearance. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijms23031542 |
It is part of: | International Journal of Molecular Sciences, 2022, vol 23, num 3 |
URI: | http://hdl.handle.net/2445/183907 |
Related resource: | https://doi.org/10.3390/ijms23031542 |
ISSN: | 1422-0067 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Publicacions de projectes de recerca finançats per la UE |
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