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Title: Epilepsy in Neurodegenerative Diseases: Related Drugs and Molecular Pathways
Author: Cano Fernández, Amanda
Fonseca, Elena
Ettcheto Arriola, Miren
Sánchez-López, E. (Elena)
Rojas, Itziar de
Alonso Lana, Silvia
Morató Arús, Xavier
Souto, Eliana B.
Toledo, Manuel
Boada, Mercè
Marquié, Marta
Ruiz, Agustín
Keywords: Malalties neurodegeneratives
Malaltia d'Alzheimer
Malaltia de Parkinson
Neurodegenerative Diseases
Alzheimer's disease
Parkinson's disease
Issue Date: 2021
Publisher: MDPI
Abstract: Epilepsy is a chronic disease of the central nervous system characterized by an electrical imbalance in neurons. It is the second most prevalent neurological disease, with 50 million people affected around the world, and 30% of all epilepsies do not respond to available treatments. Currently, the main hypothesis about the molecular processes that trigger epileptic seizures and promote the neurotoxic effects that lead to cell death focuses on the exacerbation of the glutamate pathway and the massive influx of Ca2+ into neurons by different factors. However, other mechanisms have been proposed, and most of them have also been described in other neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, or multiple sclerosis. Interestingly, and mainly because of these common molecular links and the lack of effective treatments for these diseases, some antiseizure drugs have been investigated to evaluate their therapeutic potential in these pathologies. Therefore, in this review, we thoroughly investigate the common molecular pathways between epilepsy and the major neurodegenerative diseases, examine the incidence of epilepsy in these populations, and explore the use of current and innovative antiseizure drugs in the treatment of refractory epilepsy and other neurodegenerative diseases. Keywords: Alzheimer's disease; Huntington's disease; Parkinson's disease; epilepsy; multiple sclerosis; neurodegenerative diseases.
Note: Reproducció del document publicat a:
It is part of: Pharmaceuticals, 2021, vol. 14, num. 10, p. 1057
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ISSN: 1424-8247
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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