Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/183957
Title: | Clinical approach to the diagnosis of autoimmune encephalitis in the pediatric patient |
Author: | Cellucci, Tania Mater, Heather van Graus, Francesc Muscal, Eyal Gallentine, William Klein-Gitelman, Marisa S. Benseler, Susanne M. Frankovich, Jennifer Gorman, Marck P. Haren, Keith van Dalmau, Josep Dale, Russell C. |
Keywords: | Infants Encefalitis Children Encephalitis |
Issue Date: | 1-Mar-2020 |
Publisher: | Wolters Kluwer on behalf of the American Academy of Neurology |
Abstract: | Autoimmune encephalitis (AE) is an important and treatable cause of acute encephalitis. Diagnosis of AE in a developing child is challenging because of overlap in clinical presentations with other diseases and complexity of normal behavior changes. Existing diagnostic criteria for adult AE require modification to be applied to children, who differ from adults in their clinical presentations, paraclinical findings, autoantibody profiles, treatment response, and long-term outcomes.A subcommittee of the Autoimmune Encephalitis International Working Group collaborated through conference calls and email correspondence to consider the pediatric-specific approach to AE. The subcommittee reviewed the literature of relevant AE studies and sought additional input from other expert clinicians and researchers.Existing consensus criteria for adult AE were refined for use in children. Provisional pediatric AE classification criteria and an algorithm to facilitate early diagnosis are proposed. There is also discussion about how to distinguish pediatric AE from conditions within the differential diagnosis.Diagnosing AE is based on the combination of a clinical history consistent with pediatric AE and supportive diagnostic testing, which includes but is not dependent on antibody testing. The proposed criteria and algorithm require validation in prospective pediatric cohorts.Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. |
Note: | Reproducció del document publicat a: https://doi.org/10.1212/NXI.0000000000000663 |
It is part of: | Neurology-Neuroimmunology & Neuroinflammation, 2020, vol 7, num 2 |
URI: | http://hdl.handle.net/2445/183957 |
Related resource: | https://doi.org/10.1212/NXI.0000000000000663 |
ISSN: | 2332-7812 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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12474_6160305_17_cellucci.pdf | 3.3 MB | Adobe PDF | View/Open |
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