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DC Field | Value | Language |
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dc.contributor.author | Joubert, Bastien | - |
dc.contributor.author | García Serra, Anna | - |
dc.contributor.author | Planaguma, Jesús | - |
dc.contributor.author | Martinez Hernandez, Eugenia | - |
dc.contributor.author | Kraft, Andrea | - |
dc.contributor.author | Palm, Frederick | - |
dc.contributor.author | Iizuka, Takahiro | - |
dc.contributor.author | Honnorat, Jérôme | - |
dc.contributor.author | Leypoldt, Frank | - |
dc.contributor.author | Graus Ribas, Francesc | - |
dc.contributor.author | Dalmau, Josep | - |
dc.date.accessioned | 2022-03-09T15:37:52Z | - |
dc.date.available | 2022-03-09T15:37:52Z | - |
dc.date.issued | 2020-05-01 | - |
dc.identifier.issn | 2332-7812 | - |
dc.identifier.uri | http://hdl.handle.net/2445/183959 | - |
dc.description.abstract | To report the effects of anti-NMDA receptor (NMDAR) encephalitis in pregnant patients and their babies.We studied a retrospective cohort of patients who developed anti-NMDAR encephalitis during pregnancy or became pregnant while recovering from the encephalitis. In addition, we reviewed the English literature between 2010 and 2019 related to this topic.We studied 11 patients; 6 developed anti-NMDAR encephalitis during pregnancy, and 5 became pregnant while recovering. There were no obstetrical complications, but 6 (55%) babies were premature. Ten newborns were healthy, and 1 (9%) developed transient respiratory distress. Nine infants had assessable follow-up (median 18 months; range, 7-96 months), and all showed normal development. We identified 21 cases in the English literature. Obstetrical complications occurred in 7 (33%) pregnancies. Two patients died of septic shock (1 baby successfully delivered), another 2 had miscarriages, and in 2, the pregnancy was terminated. Sixteen babies (76%) were delivered, 9 (56%) premature. At birth, 13/16 (81%) newborns were healthy, 2/16 (13%) had transient neurologic or respiratory symptoms, and 1 (6%) died of brain edema. Follow-up (median 12 months; range, 6-36 months) was reported for 8 children: 7 (88%) showed normal development and behavior, and 1 (13%) cortical dysplasia. Immunotherapy was used during pregnancy in 7 (64%) of our patients and 18 (86%) of the reported cases, including rituximab in 4 cases, without adverse effects.Patients who develop anti-NMDAR encephalitis during pregnancy or become pregnant during recovery often have obstetrical complications, but most of the newborns are healthy and appear to have normal development.Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1212/NXI.0000000000000668 | - |
dc.relation.ispartof | Neurology-Neuroimmunology & Neuroinflammation, 2020, vol 7, num 3 | - |
dc.relation.uri | https://doi.org/10.1212/NXI.0000000000000668 | - |
dc.rights | cc by-nc-nd (c) Joubert, Bastien et al, 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) | - |
dc.subject.classification | Encefalitis | - |
dc.subject.classification | Embaràs | - |
dc.subject.other | Encephalitis | - |
dc.subject.other | Pregnancy | - |
dc.title | Pregnancy outcomes in anti-NMDA receptor encephalitis: Case series | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-03-08T15:23:20Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 6160304 | - |
dc.identifier.pmid | 31948997 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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12474_6160304_42_joubert_pregnancy.pdf | 116.92 kB | Adobe PDF | View/Open |
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