Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/184033
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Alegre-Zurano, Laia | - |
dc.contributor.author | López-Arnau, Raúl | - |
dc.contributor.author | Luján, Miguel Á. | - |
dc.contributor.author | Camarasa García, Jordi | - |
dc.contributor.author | Valverde, O. | - |
dc.date.accessioned | 2022-03-11T08:29:14Z | - |
dc.date.available | 2022-03-11T08:29:14Z | - |
dc.date.issued | 2021-08-02 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/2445/184033 | - |
dc.description.abstract | : 3,4-Methylenedioxypyrovalerone (MDPV) is a new psychoactive substance (NPS) and the most widespread and life-threatening synthetic cathinone of the "bath salts". Preclinical research has proven the cocaine-like psychostimulant effects of MDPV and its potential for abuse. Cannabidiol (CBD) is a non-psychotropic phytocannabinoid that has emerged as a new potential treatment for drug addiction. Here, we tested the effects of CBD (20 mg/kg) on MDPV (2 mg/kg)-induced conditioned place preference and MDPV (0.05 and 0.075 mg/kg/infusion) self-administration paradigms. In addition, we assessed the effects of the co-administration of CBD and MDPV (3 and 4 mg/kg) on anxietylike behaviour using the elevated plus maze (EPM). CBD mitigated the MDPV-induced conditioned place preference. On the contrary, CBD administration throughout the MDPV (0.075 mg/kg/infusion) self-administration increased drug-seeking and taking behaviours, but only in the high-responders group of mice. Furthermore, CBD exerted anxiolytic-like effects, exclusively in MDPV-treated mice. Taken together, our results indicate that CBD modulation of MDPV-induced motivational responses in mice varies depending on the requirements of the learning task, resulting in a complex response. Therefore, further research attempting to decipher the behavioural and molecular interactions between CBD and MDPV is needed. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/ijms22158304 | - |
dc.relation.ispartof | International Journal of Molecular Sciences, 2021, vol. 2021, num. 22, p. 8304-8317 | - |
dc.relation.uri | https://doi.org/10.3390/ijms22158304 | - |
dc.rights | cc-by (c) Alegre-Zurano, Laia et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) | - |
dc.subject.classification | Cànnabis | - |
dc.subject.classification | Ansietat | - |
dc.subject.classification | Farmacologia | - |
dc.subject.other | Cannabis | - |
dc.subject.other | Anxiety | - |
dc.subject.other | Pharmacology | - |
dc.title | Cannabidiol Modulates the Motivational and Anxiety-Like Effects of 3,4-Methylenedioxypyrovalerone (MDPV) in Mice | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 716586 | - |
dc.date.updated | 2022-03-11T08:29:15Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
716586.pdf | 1.82 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License