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DC Field | Value | Language |
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dc.contributor.author | Molina García, Mariola | - |
dc.contributor.author | Fraguas, David | - |
dc.contributor.author | Del Rey Mejias, Angel | - |
dc.contributor.author | Mezquida Mateos, Gisela | - |
dc.contributor.author | Sánchez-Torres, Ana M. | - |
dc.contributor.author | Amoretti Guadall, Silvia | - |
dc.contributor.author | Lobo, Antonio | - |
dc.contributor.author | González-Pinto, Ana | - |
dc.contributor.author | Andreu-Bernabeu, Álvaro | - |
dc.contributor.author | Corripio, Iluminada | - |
dc.contributor.author | Vieta i Pascual, Eduard, 1963- | - |
dc.contributor.author | Baeza, Inmaculada, 1970- | - |
dc.contributor.author | Mané Santacana, Anna | - |
dc.contributor.author | Cuesta, Manuel J. | - |
dc.contributor.author | Serna Gómez, Elena de la | - |
dc.contributor.author | Payá, Beatriz | - |
dc.contributor.author | Zorrilla, Iñaki | - |
dc.contributor.author | Arango, Celso | - |
dc.contributor.author | Bernardo Arroyo, Miquel | - |
dc.contributor.author | Rapado-Castro, Marta | - |
dc.contributor.author | Parellada, Mara | - |
dc.contributor.author | PEPs Group | - |
dc.date.accessioned | 2022-03-17T15:44:52Z | - |
dc.date.available | 2022-03-17T15:44:52Z | - |
dc.date.issued | 2021-06-02 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | http://hdl.handle.net/2445/184200 | - |
dc.description.abstract | Background: premorbid IQ (pIQ) and age of onset are predictors of clinical severity and long-term functioning after a first episode of psychosis. However, the additive influence of these variables on clinical, functional, and recovery rates outcomes is largely unknown. Methods: we characterized 255 individuals who have experienced a first episode of psychosis in four a priori defined subgroups based on pIQ (low pIQ < 85; average pIQ ≥ 85) and age of onset (early onset < 18 years; adult onset ≥ 18 years). We conducted clinical and functional assessments at baseline and at two-year follow-up. We calculated symptom remission and recovery rates using the Positive and Negative Symptoms of Schizophrenia Schedule (PANSS) and the Global Assessment Functioning (GAF or Children-GAF). We examined clinical and functional changes with pair-wise comparisons and two-way mixed ANOVA. We built hierarchical lineal and logistic regression models to estimate the predictive value of the independent variables over functioning or recovery rates. Results: early-onset patients had more severe positive symptoms and poorer functioning than adult-onset patients. At two-year follow-up, only early-onset with low pIQ and adult-onset with average pIQ subgroups differed consistently, with the former having more negative symptoms (d = 0.59), poorer functioning (d = 0.82), lower remission (61% vs. 81.1%), and clinical recovery (34.1% vs. 62.2%). Conclusions: early-onset individuals with low pIQ may present persistent negative symptoms, lower functioning, and less recovery likelihood at two-year follow-up. Intensive cognitive and functional programs for these individuals merit testing to improve long-term recovery rates in this subgroup. | - |
dc.format.extent | 19 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/jcm10112474 | - |
dc.relation.ispartof | Journal of Clinical Medicine, 2021, vol. 10, num. 11, p. 2474 | - |
dc.relation.uri | https://doi.org/10.3390/jcm10112474 | - |
dc.rights | cc-by (c) Molina García, Mariola et al., 2021 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Psicosi | - |
dc.subject.classification | Pronòstic mèdic | - |
dc.subject.other | Psychoses | - |
dc.subject.other | Prognosis | - |
dc.title | The Role of Premorbid IQ and Age of Onset as Useful Predictors of Clinical, Functional Outcomes, and Recovery of Individuals with a First Episode of Psychosis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 714454 | - |
dc.date.updated | 2022-03-17T15:44:52Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/777394/EU//AIMS-2-TRIALS | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/602478/EU//METSY | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/603196/EU//PSYSCAN | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/115916/EU//PRISM | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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714454.pdf | 3.48 MB | Adobe PDF | View/Open |
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