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DC Field | Value | Language |
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dc.contributor.author | Veloso, Sergi | - |
dc.contributor.author | Olona, Montserrat | - |
dc.contributor.author | García Alcaide, Felipe | - |
dc.contributor.author | Domingo, Pere (Domingo Pedrol) | - |
dc.contributor.author | Alonso-Villaverde, Carlos | - |
dc.contributor.author | Broch, Montserrat | - |
dc.contributor.author | Peraire, Joaquim | - |
dc.contributor.author | Vilades, Consuelo | - |
dc.contributor.author | Plana Prades, Montserrat | - |
dc.contributor.author | Pedrol, Enric | - |
dc.contributor.author | López Dupla, Miguel | - |
dc.contributor.author | Aguilar, Carmen | - |
dc.contributor.author | Gutierrez, Mar | - |
dc.contributor.author | Leon, Agathe | - |
dc.contributor.author | Tasias, Mariona | - |
dc.contributor.author | Gatell, José M. | - |
dc.contributor.author | Richart, Cristobal | - |
dc.contributor.author | Vidal, Francesc | - |
dc.date.accessioned | 2022-03-18T17:48:33Z | - |
dc.date.available | 2022-03-18T17:48:33Z | - |
dc.date.issued | 2010-04-26 | - |
dc.identifier.issn | 1471-2350 | - |
dc.identifier.uri | http://hdl.handle.net/2445/184241 | - |
dc.description.abstract | Background: Tumor necrosis factor alpha (TNF-α) is thought to be involved in the various immunogenetic events that influence HIV-1 infection. Methods: We aimed to determine whether carriage of the TNF-α-238G>A, -308G>A and -863 C>A gene promoter single nucleotide polymorphisms (SNP) and the CCR5Δ32 variant allele influence the risk of HIV-1 infection and disease progression in Caucasian Spaniards. The study group consisted of 423 individuals. Of these, 239 were uninfected (36 heavily exposed but uninfected [EU] and 203 healthy controls [HC]) and 184 were HIV-1-infected (109 typical progressors [TP] and 75 long-term nonprogressors [LTNP] of over 16 years' duration). TNF-α SNP and the CCR5Δ32 allele were assessed using PCR-RFLP and automatic sequencing analysis methods on white blood cell DNA. Genotype and allele frequencies were compared using the χ 2 test and the Fisher exact test. Haplotypes were compared by logistic regression analysis. Results: The distribution of TNF-α-238G>A, -308G>A and -863 C>A genetic variants was non-significantly different in HIV-1-infected patients compared with uninfected individuals: -238G>A, p = 0.7 and p = 0.3; -308G>A, p = 0.05 and p = 0.07; -863 C>A, p = 0.7 and p = 0.4, for genotype and allele comparisons, respectively. Haplotype analyses, however, indicated that carriers of the haplotype H3 were significantly more common among uninfected subjects (p = 0.04). Among the infected patients, the distribution of the three TNF-α genetic variants assessed was non-significantly different between TP and LTNP: -238G>A, p = 0.35 and p = 0.7; -308G>A, p = 0.7 and p = 0.6: -863 C>A, p = 0.2 and p = 0.2, for genotype and allele comparisons, respectively. Haplotype analyses also indicated non-significant associations. Subanalyses in the LTNP subset indicated that the TNF-α-238A variant allele was significantly overrepresented in patients who spontaneously controlled plasma viremia compared with those who had a detectable plasma viral load (genotype comparisons, p = 0.02; allele comparisons, p = 0.03). The CCR5Δ32 distribution was non-significantly different in HIV-1-infected patients with respect to the uninfected population (p = 0.15 and p = 0.2 for genotype and allele comparisons, respectively) and in LTNP vs TP (p = 0.4 and p = 0.5 for genotype and allele comparisons, respectively). Conclusions: In our cohort of Caucasian Spaniards, TNF-α genetic variants could be involved in the vulnerability to HIV1 infection. TNF-α genetic variants were unrelated to disease progression in infected subjects. The -238G>A SNP may modulate the control of viremia in LTNP. Carriage of the CCR5Δ32 variant allele had no effect on the risk of infection and disease progression. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/1471-2350-11-63 | - |
dc.relation.ispartof | BMC Medical Genetics, 2010, vol. 11, num. (2), p. 63 | - |
dc.relation.uri | https://doi.org/10.1186/1471-2350-11-63 | - |
dc.rights | cc-by (c) Veloso, Sergi et al., 2010 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Infeccions per VIH | - |
dc.subject.classification | Necrosi | - |
dc.subject.classification | Espanyols | - |
dc.subject.classification | Genètica | - |
dc.subject.other | HIV infections | - |
dc.subject.other | Necrosis | - |
dc.subject.other | Spaniards | - |
dc.subject.other | Genetics | - |
dc.title | Effect of TNF-a genetic variants and CCR5 Delta 32 on the vulnerability to HIV-1 infection and disease progression in Caucasian Spaniards | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 693529 | - |
dc.date.updated | 2022-03-18T17:48:34Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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