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Title: | FGF21 serum levels are related to insulin resistance, metabolic changes and obesity in Mexican people living with HIV (PLWH). |
Author: | Urraza-Robledo, Arguiñe Ivonne Giralt i Oms, Marta González-Galarza, Faviel Francisco Villarroya i Gombau, Francesc Miranda Pérez, Alberto Alejandro Ruiz Flores, Pablo Gutiérrez Pérez, María Elena Domingo, Pere (Domingo Pedrol) López-Márquez Francisco Carlos |
Keywords: | Infeccions per VIH Hormones peptídiques HIV infections Peptide hormones |
Issue Date: | 21-May-2021 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Antiretroviral therapy has significantly improved prognosis in treatment against HIV infection, however, prolonged exposure is associated to cardiovascular diseases, lipodystrophy, type 2 diabetes, insulin resistance, metabolic alteration, as obesity which includes the accumulation of oxidative stress in adipose tissue. FGF21 is a peptide hormone that is known to regulate glucose and lipid metabolism. FGF21 is expressed and secreted primarily in the liver and adipose tissue, promoting oxidation of glucose/fatty acids and insulin sensitivity. Alterations in FGF21 may be associated with the development of insulin resistance, metabolic syndrome and cardiovascular disease. We hypothesized that FGF21 protein levels are associated with metabolic abnormalities, placing special attention to the alterations in relation to the concurrence of overweight/obesity in people living with HIV (PLWH). |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0252144 |
It is part of: | PLoS One, 2021, vol. 16, num. 5, p. e0252144 |
URI: | http://hdl.handle.net/2445/184269 |
Related resource: | https://doi.org/10.1371/journal.pone.0252144 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
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